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EBI2/GPR183

G-protein coupled receptor 183 also known as Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2) is a protein that in humans is encoded by the GPR183 gene.[5] This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of the Burkitt's lymphoma cell line BL41.[6] This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes.[5]

SAE-14
T99751241280-25-0
SAE-14 is a specific GPR183 antagonist. SAE-14 inhibits GPR183 with an IC50 of 28.5 nM in a calcium mobilization assay[1].
  • $58
In Stock
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NIBR189
T71561599432-08-2
NIBR189 is a potent and selective antagonist of EBI2 (GPR183) receptor (IC50 of 11 and 15 nM for human and mouse EBI2 receptors, respectively)
  • $30
In Stock
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ML401
T82341597489-14-9
ML401 is a selectively EBI2(GPR183) receptor antagonist(IC50 of 1.03 nM) .
  • $84
In Stock
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7α,25-Dihydroxycholesterol
T1406364907-22-8
7α,25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist, as well as an endogenous ligand, of the orphan GPCR receptor EBI2 (GPR183). It serves as a chemokine directing the migration of B cells, T cells, and dendritic cells and exhibits high potency in activating EBI2 (EC50=140 pM; Kd=450 pM) [1][2].
  • $253
35 days
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GSK682753A
T114981334294-76-6
GSK682753A is a selective and highly potent inverse agonist of the Epstein-Barr virus-induced receptor 2 (EBI2) with an IC50 of 53.6 nM.
  • $95
5 days
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GPR183-IN-2
T885002924064-10-6
GPR183-IN-2 (compound 23) is an effective, orally active inhibitor of GPR183, displaying an IC50 value of 39.45 nM in Ca2+ mobilization assays. This compound has potential applications in research related to cancer, autoimmune diseases, pain, and osteoporosis.
  • $1,520
6-8 weeks
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GPR183 antagonist-2
T865192924063-98-7
GPR183 antagonist-2 (compound 32), a selective antagonist of GPR183, exhibits excellent water solubility and pharmacokinetic properties. This compound effectively diminishes paw and joint swelling, and reduces gene expression of pro-inflammatory cytokines (MCP-1, MMPs, and VEGF) in a dose-dependent manner within a collagen-induced arthritis (CIA) mouse model. GPR183 antagonist-2 is applicable in researching autoimmune diseases [1].
  • $1,520
6-8 weeks
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GPR183-IN-1
T885272924063-70-5
GPR183-IN-1 (compound 15) is an effective orally active inhibitor of GPR183. It inhibits Ca2+ mobilization with an IC50 value of 39.97 nM. GPR183-IN-1 holds potential for research in cancer, autoimmune diseases, pain, and osteoporosis.
  • $1,520
2-4 weeks
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