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Anti-LY6E Antibody (6P153)
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Catalog No. TMAH-00712
Anti-LY6E Antibody (6P153) is an antibody targeting LY6E. Anti-LY6E Antibody (6P153) can be used in ELISA, IF.
Anti-LY6E Antibody (6P153)
Anti-LY6E Antibody (6P153)
😃Good
Catalog No. TMAH-00712
Anti-LY6E Antibody (6P153) is an antibody targeting LY6E. Anti-LY6E Antibody (6P153) can be used in ELISA, IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | 197 € | 7-10 days | |
| 100 μL | 329 € | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Monoclonal Application: ELISA, IF Reactivity: Human |
| Ig Type | mIgG2a |
| Clone | 6P153 |
| Reactivity | Human |
| Verified Activity | 1. Immunofluorescence staining of A549 cell with TMAH-00712 at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L). 2. The Binding Activity of Human LY6E with Anti-LY6E recombinant antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Human LY6E protein at 2 μg/mL can bind Anti-LY6E recombinant antibody. The EC50 is 2.483-3.282 ng/mL. |
| Application | ELISA, IF |
| Recommended Dose | IF:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cell membrane; Lipid-anchor, GPI-anchor. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Research Background | GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation. Restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. Plays also an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. (Microbial infection) Promotes entry, likely through an enhanced virus-cell fusion process, of various viruses including HIV-1, West Nile virus, dengue virus and Zika virus. In contrast, the paramyxovirus PIV5, which enters at the plasma membrane, does not require LY6E. Mechanistically, adopts a microtubule-like organization upon viral infection and enhances viral uncoating after endosomal escape. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human LY6E Protein |
| Antigen Species | Human |
| Gene ID | 4061 |
| Uniprot ID | |
| Biology Area | Cell biology |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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