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Homo-PROTAC pVHL30 degrader 1

🥰Excellent
Catalog No. T13722Cas No. 2244684-49-7

Homo-PROTAC pVHL30 degrader 1 is a potent PROTAC-based degrader of pVHL30.

Homo-PROTAC pVHL30 degrader 1

Homo-PROTAC pVHL30 degrader 1

🥰Excellent
Purity: 98.95%
Catalog No. T13722Cas No. 2244684-49-7
Homo-PROTAC pVHL30 degrader 1 is a potent PROTAC-based degrader of pVHL30.
Pack SizePriceAvailabilityQuantity
1 mg$30In Stock
5 mg$77In Stock
10 mg$98In Stock
25 mg$197In Stock
50 mg$317In Stock
100 mg$461In Stock
200 mg$649In Stock
1 mL x 10 mM (in DMSO)$119In Stock
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Batch Information

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Purity:98.95%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
Homo-PROTAC pVHL30 degrader 1 is a potent PROTAC-based degrader of pVHL30.
In vitro
Homo-PROTAC pVHL30 degrader 1 dimerizes von Hippel-Lindau (VHL) with high avidity in vitro and induces rapid, potent, and proteasome-dependent self-degradation of VHL in different cell lines, in a highly isoform-selective fashion and without triggering a hypoxic response.
Chemical Properties
Molecular Weight1179.45
FormulaC58H82N8O14S2
Cas No.2244684-49-7
SmilesC([C@@H](NC(COCCOCCOCCOCCOCCOCC(N[C@H](C(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1)[C@@](C)(C)C)=O)=O)[C@@](C)(C)C)(=O)N4[C@H](C(NCC5=CC=C(C=C5)C6=C(C)N=CS6)=O)C[C@@H](O)C4
Relative Density.1.266 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 150 mg/mL (127.18 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (3.39 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.8479 mL4.2393 mL8.4785 mL42.3926 mL
5 mM0.1696 mL0.8479 mL1.6957 mL8.4785 mL
10 mM0.0848 mL0.4239 mL0.8479 mL4.2393 mL
20 mM0.0424 mL0.2120 mL0.4239 mL2.1196 mL
50 mM0.0170 mL0.0848 mL0.1696 mL0.8479 mL
100 mM0.0085 mL0.0424 mL0.0848 mL0.4239 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

VHLPROTACsInhibitorinhibitHomo-PROTAC pVHL-30 degrader 1Homo-PROTAC pVHL30 degrader 1HomoPROTAC pVHL30 degrader 1Homo PROTAC pVHL30 degrader 1
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