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Homo-PROTAC pVHL30 degrader 1

Name: Homo-PROTAC pVHL30 degrader 1
Brand: TargetMol
SKU: T13722
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13722Cas No. 2244684-49-7

Homo-PROTAC pVHL30 degrader 1 is a potent PROTAC-based degrader of pVHL30.

Homo-PROTAC pVHL30 degrader 1

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🥰Excellent

Purity: 98.95%

Catalog No. T13722Cas No. 2244684-49-7

Homo-PROTAC pVHL30 degrader 1 is a potent PROTAC-based degrader of pVHL30.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$46	In Stock	In Stock
10 mg	$59	In Stock	In Stock
25 mg	$118	In Stock	In Stock
50 mg	$190	In Stock	In Stock
100 mg	$277	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$71	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.95%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Homo-PROTAC pVHL30 degrader 1 is a potent PROTAC-based degrader of pVHL30.
In vitro	Homo-PROTAC pVHL30 degrader 1 dimerizes von Hippel-Lindau (VHL) with high avidity in vitro and induces rapid, potent, and proteasome-dependent self-degradation of VHL in different cell lines, in a highly isoform-selective fashion and without triggering a hypoxic response.

Chemical Properties

Molecular Weight	1179.45
Formula	C₅₈H₈₂N₈O₁₄S₂
Cas No.	2244684-49-7
Smiles	C([C@@H](NC(COCCOCCOCCOCCOCCOCC(N[C@H](C(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1)[C@@](C)(C)C)=O)=O)[C@@](C)(C)C)(=O)N4[C@H](C(NCC5=CC=C(C=C5)C6=C(C)N=CS6)=O)C[C@@H](O)C4
Relative Density.	1.266 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (127.18 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (3.39 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8479 mL	4.2393 mL	8.4785 mL	42.3926 mL
5 mM	0.1696 mL	0.8479 mL	1.6957 mL	8.4785 mL
10 mM	0.0848 mL	0.4239 mL	0.8479 mL	4.2393 mL
20 mM	0.0424 mL	0.2120 mL	0.4239 mL	2.1196 mL
50 mM	0.0170 mL	0.0848 mL	0.1696 mL	0.8479 mL
100 mM	0.0085 mL	0.0424 mL	0.0848 mL	0.4239 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc