ITPase Protein, Human, Recombinant (His)

Name: ITPase Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPJ-01308
Rating: 4.5 (1 reviews)

(Synonyms: Putative Oncog, Nucleoside-Triphosphate Pyrophosphatase, Nucleoside-Triphosphate Diphosphatase, NTPase, Non-Standard Purine NTP Pyrophosphatase, Non-Canonical Purine NTP Pyrophosphatase, ITPase, Inosine Triphosphate Pyrophosphatase, Inosine Triphosphatase) Copy Product Info

Synonyms: Putative Oncog, Nucleoside-Triphosphate Pyrophosphatase, Nucleoside-Triphosphate Diphosphatase, NTPase, Non-Standard Purine NTP Pyrophosphatase, Non-Canonical Purine NTP Pyrophosphatase, ITPase, Inosine Triphosphate Pyrophosphatase, Inosine Triphosphatase

Catalog No. TMPJ-01308 Copy Product Info

Inosine Triphosphate Pyrophosphatase (ITPase) is a cytoplasmic enzyme that belongs to the HAM1 NTPase family. ITPase hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP) and deoxyinosine triphosphate (dITP) to the monophosphate nucleotide (IMP) and diphosphate. The ITPase enzyme acts as a homodimer and does not distinguish between the deoxy- and ribose forms. ITPase probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Defects in ITPase is thought to be inherited and is characterized by an over-accumulation of ITP in erythocytes, leukocytes and fibroblasts.

ITPase Protein, Human, Recombinant (His)

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Pack Size	Price	USA Stock	Global Stock
10 µg	$183	7-10 days	7-10 days
20 µg	$292	7-10 days	7-10 days
50 µg	$545	7-10 days	7-10 days
100 µg	$792	7-10 days	7-10 days
200 µg	$1,150	7-10 days	7-10 days
500 µg	$1,900	7-10 days	7-10 days
1 mg	$2,730	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	Inosine Triphosphate Pyrophosphatase (ITPase) is a cytoplasmic enzyme that belongs to the HAM1 NTPase family. ITPase hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP) and deoxyinosine triphosphate (dITP) to the monophosphate nucleotide (IMP) and diphosphate. The ITPase enzyme acts as a homodimer and does not distinguish between the deoxy- and ribose forms. ITPase probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Defects in ITPase is thought to be inherited and is characterized by an over-accumulation of ITP in erythocytes, leukocytes and fibroblasts.
Species	Human
Expression System	E. coli
Tag	C-6xHis
Accession Number	Q9BY32
Amino Acid	Ala2-Ala194
Construction	Ala2-Ala194
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 5% Trehalose, 300 mM NaCl, 30% Glycerol, 0.05% Tween 80, pH8.0.
Synonyms	Putative Oncog, Nucleoside-Triphosphate Pyrophosphatase, Nucleoside-Triphosphate Diphosphatase, NTPase, Non-Standard Purine NTP Pyrophosphatase, Non-Canonical Purine NTP Pyrophosphatase, ITPase, Inosine Triphosphate Pyrophosphatase, Inosine Triphosphatase
Research Background	Inosine Triphosphate Pyrophosphatase (ITPase) is a cytoplasmic enzyme that belongs to the HAM1 NTPase family. ITPase hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP) and deoxyinosine triphosphate (dITP) to the monophosphate nucleotide (IMP) and diphosphate. The ITPase enzyme acts as a homodimer and does not distinguish between the deoxy- and ribose forms. ITPase probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Defects in ITPase is thought to be inherited and is characterized by an over-accumulation of ITP in erythocytes, leukocytes and fibroblasts.

Chemical Properties

Molecular Weight

21 KDa (reducing condition)

Storage & Solubility Information

Shipping	Proteins are shipped with blue ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.