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Managlinat dialanetil (Synonyms: MB06322, MB 6322, CS-917)

Name: Managlinat dialanetil
Brand: TargetMol
SKU: T16009L
Price: 140 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T16009L Copy Product Info

Purity: 99.63%

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Managlinat dialanetil (MB06322) is an orally available and potent fructose 1,6-bisphosphatase (FBPase) inhibitor with hypoglycaemic activity for the study of type 2 diabetes.

Managlinat dialanetil

Copy Product Info

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Catalog No. T16009L

Synonyms MB06322, MB 6322, CS-917

Managlinat dialanetil (MB06322) is an orally available and potent fructose 1,6-bisphosphatase (FBPase) inhibitor with hypoglycaemic activity for the study of type 2 diabetes.

Cas No. 280782-97-0

Pack Size	Price	USA Stock	Global Stock
1 mg	$140	In Stock	In Stock
5 mg	$347	In Stock	In Stock
10 mg	$551	In Stock	In Stock
25 mg	$828	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.63%

ee:100%

Appearance:Solid

Color:White to Yellow

Resource Download

COA LCMS CSFC HNMR

Product Introduction

Bioactivity

Description	Managlinat dialanetil (MB06322) is an orally available and potent fructose 1,6-bisphosphatase (FBPase) inhibitor with hypoglycaemic activity for the study of type 2 diabetes.
In vivo	Dose-dependently inhibiting gluconeogenesis (GNG), managlinat dialanetil also lowers basal and postprandial blood glucose levels in Zucker diabetic fatty (ZDF) rats after oral administration[1].
Synonyms	MB06322, MB 6322, CS-917

Chemical Properties

Molecular Weight	500.55
Formula	C₂₁H₃₃N₄O₆PS
Cas No.	280782-97-0
Smiles	C(C(C)C)C1=C(N=C(N)S1)C=2OC(P(N[C@H](C(OCC)=O)C)(N[C@H](C(OCC)=O)C)=O)=CC2
Relative Density.	1.26 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (39.96 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9978 mL	9.9890 mL	19.9780 mL	99.8901 mL
5 mM	0.3996 mL	1.9978 mL	3.9956 mL	19.9780 mL
10 mM	0.1998 mL	0.9989 mL	1.9978 mL	9.9890 mL
20 mM	0.0999 mL	0.4995 mL	0.9989 mL	4.9945 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc