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gamma-DGG acetate(6729-55-1 free base)

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Catalog No. T15369LCas No. 2935387-13-4
Alias γ-D-Glutamylglycine, γDGG

gamma-DGG acetate(6729-55-1 free base) (γ-D-Glutamylglycine) is a competitive blocker of AMPA receptor.

gamma-DGG acetate(6729-55-1 free base)
Other Forms of gamma-DGG acetate(6729-55-1 free base):

gamma-DGG acetate(6729-55-1 free base)

🥰Excellent
Purity: 99.81%
Catalog No. T15369LAlias γ-D-Glutamylglycine, γDGGCas No. 2935387-13-4
gamma-DGG acetate(6729-55-1 free base) (γ-D-Glutamylglycine) is a competitive blocker of AMPA receptor.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$39In StockIn Stock
50 mg$48In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.81%
Appearance:Solid
Color:White
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
gamma-DGG acetate(6729-55-1 free base) (γ-D-Glutamylglycine) is a competitive blocker of AMPA receptor.
In vitro
gamma-DGG (γ-DGG) acetate is the most effective antagonist of the excitatory postsynaptic potentials (e.p.s.p.s). Its action is reversible and not associated with any change in the passive membrane properties of the granule cells or in the apparent reversal potential of the e.p.s.p.gamma-DGG blocks less at higher glutamate concentration. gamma-DGG (200-400 μM) in the bath decreases the miniature EPSC (mEPSC) amplitude by 26±2% (n=5 synapses) and shifts both the mEPSC amplitude distribution and the cumulative probability curve to the left[1]. The quantal analysis displays that the reduction in the e.p.s.p. paralleled the reduction in quantal size rather than quantal content, confirming a post-synaptic site of the action of gamma-DGG[2].
Synonymsγ-D-Glutamylglycine, γDGG
Chemical Properties
Molecular Weight264.23
FormulaC9H16N2O7
Cas No.2935387-13-4
SmilesCC(O)=O.O=C(O)CNC(CC[C@H](C(O)=O)N)=O
Relative Density.no data available
SequenceH-D-gGlu-Gly-OH
Sequence ShortXG
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 50 mg/mL (189.23 mM), Sonication is recommended.
DMSO: Slightly soluble
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM3.7846 mL18.9229 mL37.8458 mL189.2291 mL
5 mM0.7569 mL3.7846 mL7.5692 mL37.8458 mL
10 mM0.3785 mL1.8923 mL3.7846 mL18.9229 mL
20 mM0.1892 mL0.9461 mL1.8923 mL9.4615 mL
50 mM0.0757 mL0.3785 mL0.7569 mL3.7846 mL
100 mM0.0378 mL0.1892 mL0.3785 mL1.8923 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

r-D-GlutamylglycinerDGGgamma-D-Glutamylglycinegamma-DGG acetate(6729-55-1 free base)gammaDGG acetate(6729551 free base)gammaDGGgamma DGG acetate(6729 55 1 free base)AMPA
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