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HBV

Hepatitis B is an infectious disease caused by the hepatitis B virus (HBV) that affects the liver. It can cause both acute and chronic infection. Many people have no symptoms during the initial infection.Hepatitis B is an infectious disease caused by the hepatitis B virus (HBV) that affects the liver. It can cause both acute and chronic infection. Many people have no symptoms during the initial infection.

Doxorubicin hydrochloride
T102025316-40-9
Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I II (IC50=0.8 2.67 μM). Doxorubicin hydrochloride exhibits cytotoxicity and antitumor activity. Doxorubicin hydrochloride reduces the phosphorylation of AMPK and its downstream target protein acetyl coenzyme A carboxylase, and induces apoptosis and autophagy.
  • $34
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Linvencorvir
T642211808248-05-6In house
Linvencorvir is a hepatitis B virus (HBV) core protein variant modifier used to treat chronic HBV infection.
  • $680
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Niranthin
TN466050656-77-4
Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitive inhibitor interacting with both subunits of the enzyme. Niranthin also exhibits anti-hepatitis B virus, antiinflammatory and antiallodynic actions.
  • $198
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Tenofovir amibufenamide
T390431571076-26-0In house
Tenofovir amibufenamide (HS-10234) is a Tenofovir prodrug, an antiviral compound with oral activity. Tenofovir amibufenamide inhibits hepatitis B virus (HBV) and can be used in chronic hepatitis B (CHB) studies.
  • $233
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Azvudine
T144891011529-10-4
Azvudine (FNC) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine inhibits NRTI-resistant viral strains. Azvudine exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM).
  • $57
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Tenofovir
T1649147127-20-6
Tenofovir (GS 1278) is an adenine analog REVERSE TRANSC-RIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B. It is used to treat HIV INFECTIONS and CHRONIC HEPATITIS B, in combination with other ANTIVIRAL AGENTS, due to the emergence of ANTIVIRAL DRUG RESISTANCE when it is used alone.
  • $37
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Mulberrofuran G
TN195687085-00-5
Mulberrofuran G, isolated from Morus alba L., has anti-hepatitis B virus activity and protects against ischemic injury-induced cell death. Mulberrofuran G is a dual inhibitor of PTP1B and alpha-glucosidase for use in the study of Alzheimer's disease.
  • $263
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Bicyclol
T4121118159-48-1
Bicyclol (SY801)(SY 801) is an anti-hepatitis drug. Oral administration of bicyclol normalizes the elevated serum transaminases (ALT, AST) by 50% in chronic viral hepatitis B and C, and also has a certain level of inhibiting HBV and HCV replication. In combination therapy of bicyclol with interferon alpha, lamivudine and adefovir dipivoxil in HBV or HCV, bicyclol may reduce YMDD mutant and side effects and increase the anti-viral efficacy.
  • $57
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Swertianolin
T5S225423445-00-3
1. Swertianolin (Bellidifolin-8-O-Glucoside), mangiferin, rhodenthoside A-C, isoorientin, isovitexin, and amarogentin would serve as potential chemotaxonomic markers to differentiate Gentianaceae species. 2. Swertianolin and swertiamarin show significant hepatoprotective effect in the liver damage model induced by alpha-naphthylisot hiocyanate. 3. Swertianolin shows anti-acetylcholinesterase activity effects. 4. Swertianolin shows that it can scavenge superoxide and hydroxyl radicals with the studying method of the autoxidation of Pyrogallol and afenton.
  • $89
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Isochlorogenic acid A
T50982450-53-5
Isochlorogenic acid A (3,5-Dicaffeoylquinic acid), a natural phenolic acid, exhibits antioxidant and anti-inflammatory properties.
  • $59
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Metacavir
T28022120503-45-9In house
Metacavir (PNA) is a novel nucleoside reverse transcriptase inhibitor, a deoxyguanosine analog, with anti-hepatitis B virus (HBV) activity and mitochondrial toxicity, which can be used to study HBV infection.
  • $293
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Bulevirtide (Myrcludex B) acetate
T35373L
Bulevirtide (Myrcludex B) acetate is a viral particle entry inhibitor that blocks the hepatocyte entry pathway for viral particles, the hepatic sodium taurine co-transport polypeptide (NTCP) receptor. It can be used in HBV and HDV infection studies.
  • $197
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Linerixibat
T39781345982-69-5
Linerixibat (GSK2330672) is a highly effective, nonabsorbable ASBT inhibitor (IC50: 42 ± 3 nM) that can lower glucose in an animal model of type 2 diabetes and demonstrates excellent developability properties.
  • $76
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Isothiafludine
T27634960527-22-4In house
Isothiafludine (NZ-4) is an orally active anti-HBV compound that acts by blocking the encapsulation of pre-genomic RNA (pgRNA) and interfering with nucleosome capsid assembly, and is used in the study of HBV infections.
  • $293 TargetMol
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Canocapavir
T639712137847-19-7
Canocapavir (ZM-H1505R) is a novel orally available HBV coat protein modulator with antiviral activity that induces conformational changes in the linker region of the HBV core protein, and can be used for the treatment of hepatitis B virus.
  • $299
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Pradefovir
T28449625095-60-5
Pradefovir (Remofovir) is a reverse transcriptase inhibitor potentially for treatment of chronic HBV infection. Pradefovir is also a liver-targeted prodrug of adefovir. After metabolic activation, Pradefovir was converted to PMEA (9-(2-phosphonylmethoxyethyl)adenine) in human liver microsomes with a K(m) of 60 microM, a maximum rate of metabolism of 228 pmol min mg protein, and an intrinsic clearance of about 359 ml min.
  • $238
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RG7834
T127192072057-17-9
RG7834 (RO 7020322) is a highly selective and orally bioavailable inhibitor of HBV, targeting HBsAg, HBeAg, and HBV DNA with IC50s of 2.8 nM, 2.6 nM, and 3.2 nM, respectively, in dHepaRG Cells.
  • $31
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Tenofovir Disoproxil
T7111201341-05-1
Tenofovir Disoproxil (GS 4331) is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B.
  • $37
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ß-Thujaplicinol
T288594356-35-8In house
ß-Thujaplicinol, a hydroxylated thujaplicinone isolated from western red cedar heartwood, has antiviral activity, inhibits hepatitis B virus replication by blocking viral ribonuclease H activity, and can be used in the study of viral infections.
  • $293 TargetMol
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Helioxanthin derivative 5-4-2
T11550203935-39-1In house
Helioxanthin derivative 5-4-2 (Helioxanthin 5-4-2) is an analogue of helioxanthin that shows anti-HBV activity in vitro and can be used to study HBV.
  • $197 TargetMol
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Morphothiadin
T120971092970-12-1
Morphothiadin (GLS4) is a potent inhibitor on the replication of both wild-type and adefovir-resistant HBV (IC50 of 12 nM).
  • $97
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Punicalin
T4S171865995-64-4
Punicalin exerts anti-inflammatory, antioxidative, and anti-hepatotoxic activities, it shows inhibitory activity on HIV-1 reverse transcriptase in a dose-dependent manner, with an IC50 of 0.11 microg ml (0.14 microM).
  • $43
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Cetylpyridinium Chloride
T6439123-03-5
Cetylpyridinium Chloride (Hexadecylpyridinium Chloride) is a cationic quaternary ammonium compound used as oropharyngeal antiseptic.
  • $30
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Tenofovir Disoproxil Fumarate
T2409L202138-50-9
Tenofovir Disoproxil Fumarate (GS-1278 Disoproxil Fumarate) is a pro-drug, fumaric acid salt form of tenofovir, a nucleoside reverse transcriptase inhibitor analog of adenosine. Tenofovir disoproxil fumarate is prescribed to treat HIV and chronic hepatitis B virus (HBV) in adults.
  • $46
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Paederoside
T3S087220547-45-9
1. Paederoside is a potent deterrent against the beetle was isolated from the aphid . 2. Paederoside displays high anti-tumor promoting activity against the Epstein-Barr virus activation.
  • $130
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Pamidronate Disodium
T133757248-88-1
Pamidronate Disodium (CGP 23339A), a nitrogen-containing bisphosphonate, can help to strengthen bones.
  • $38
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OSS_128167
T4328887686-02-4
OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).
  • $38
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RO8191
T22142691868-88-9
RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.
  • $38
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Entecavir
T0085L142217-69-4
Entecavir (SQ34676) is a guanosine nucleoside analogue used in the treatment of chronic hepatitis B virus (HBV) infection. Entecavir therapy can be associated with flares of the underlying hepatitis B during or after therapy, but has not been linked to cases of clinically apparent liver injury.
  • $43
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NVR 3-778
T163661445790-55-5
NVR 3-778 is a first-in-class, orally bioavailable HBV CAM belonging to the SBA class, exhibiting anti-HBV activity.
  • $51
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Merimepodib
T3444198821-22-6
Merimepodib (VX-497) is a novel, noncompetitive inhibitor of inosine monophosphate dehydrogenase (IMPDH).
  • $39
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Catalpol
T27802415-24-9
Catalpol (Catalpinoside) is an iridoid glycoside with neuroprotective, anti-inflammatory, and anti-hepatitis virus effects.
  • $50
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Vebicorvir
T92252090064-66-5
Vebicorvir (ABI-H0731), a first-generation hepatitis B virus (HBV) core protein inhibitor, has demonstrated effective antiviral activity.
  • $54
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DDG-39
T67797119555-47-4In house
DDG-39 (1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine) possesses antiviral activity with potent and selective anti-HIV-1 and HBV activity in cell culture. The average antiviral IC50 is 0.61 μM.
  • $189
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Lagociclovir
T1570492562-88-4In house
Lagociclovir (MIV-210), a nucleoside analogue, is an antiviral compound available for the treatment of HBV82 that inhibits the replication of wild-type hepatitis B virus (HBV) in human hepatocellular carcinoma cell lines that permanently express HBV.
  • $310
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RO6889678
T90541578153-27-1
RO6889678 is HBV inhibitor with a complex ADME profile.
  • $68
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GLP-26
T114092133017-36-2
GLP-26 disrupts the encapsidation of pre-genomic RNA, causes nucleocapsid disassembly and reduces cccDNA pools. GLP-26 is a HBV capsid assembly modulators (CAM), inhibits HBV DNA replication in Hep AD38 system (IC50=3 nM), and reduces cccDNA by >90% at 1
  • $109
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Platycodin D2
TN208866663-90-9
Platycodin D2 , a less hemolytic saponin, can improve specific cellular and humoral responses to hepatitis B surface antigen in mice, it could be safely used as adjuvant eliciting Th1 and Th2 immune responses. Polygalacin D2 has anti-cancer activity, it e
  • $65
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Chamaechromone
TN148293413-00-4
Chamaechromone is a natural product isolated from the roots of Stellera chamaejasme L.. Chamaechromone has anti-HBV and insecticidal activity.
  • $113
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Vesatolimod
T68461228585-88-3
Vesatolimod (GS-9620) is an effective and specific orally active agonist of Toll-like receptor 7.
  • $45
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AT-130
T26674211364-06-6
AT-130 is a HBV virus inhibitor with improved potency (IC50 = 0.13 μM) and reduced toxicity in the HepAD38 cell line. AT-130 blocks HBV replication at the level of viral RNA packaging.
  • $35
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Osalmid
T0353526-18-1
Osalmid (Oxaphenamide) is a choleretic drug, inhibits ribonucleotide reductase activity by targeting ribonucleotide reductase small subunit M2 (RRM2).
  • $30
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Ibandronate sodium
T1599L138844-81-2
Ibandronate sodium (Boniva) is a synthetic nitrogen-containing bisphosphonate, used for the treatment of osteoporosis.
  • $76
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Pseudolaric Acid B
T192282508-31-4
Pseudolaric acid B, a natural diterpenoid compound, is isolated from Pseudolarix kaempferi.
  • $50
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Entecavir monohydrate
T0085209216-23-9
Entecavir monohydrate (BMS-200475) is a selective inhibitor of the replication of the hepatitis B virus (HBV). It, a new deoxyguanine nucleoside analog.
  • $30
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Oxethazaine
T0044126-27-2
Oxethazaine (Oxetacaine), a topical anesthetic, is used to prevent acid-induced esophageal pain.
  • $30
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AB-423
TQ00171572510-80-5
AB-423 is an inhibitor of HBV capsid assembly and effectively inhibits HBV replication (EC50 EC90: 0.08-0.27 μM 0.33-1.32 μM in cells).
  • $30
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Risedronate Sodium
T1041115436-72-1
Risedronate Sodium (NE 58095 Sodium) is an aminobisphosphonate derivative of etidronic acid and CALCIUM CHANNEL BLOCKER that inhibits BONE RESORPTION and is used for the treatment of OSTEOPOROSIS.
  • $30
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