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HBV

Hepatitis B is an infectious disease caused by the hepatitis B virus (HBV) that affects the liver. It can cause both acute and chronic infection. Many people have no symptoms during the initial infection.Hepatitis B is an infectious disease caused by the hepatitis B virus (HBV) that affects the liver. It can cause both acute and chronic infection. Many people have no symptoms during the initial infection.

  • Doxorubicin hydrochloride
    T102025316-40-9
    Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM). Doxorubicin hydrochloride exhibits cytotoxicity and antitumor activity. Doxorubicin hydrochloride reduces the phosphorylation of AMPK and its downstream target protein acetyl coenzyme A carboxylase, and induces apoptosis and autophagy.
    • $34
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  • Bulevirtide (Myrcludex B) acetate
    T35373L
    Bulevirtide (Myrcludex B) acetate is a virion entry inhibitor which blocks the virion's hepatocyte pathway of entry, the hepatic sodium/taurocholate cotransporting polypeptide (NTCP) receptor. Bulevirtide (Myrcludex B) acetate can be used in HBV and HDV infection studies.
    • $197
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  • Tenofovir
    T1649147127-20-6
    Tenofovir (GS 1278) is an adenine analog REVERSE TRANSC-RIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B. It is used to treat HIV INFECTIONS and CHRONIC HEPATITIS B, in combination with other ANTIVIRAL AGENTS, due to the emergence of ANTIVIRAL DRUG RESISTANCE when it is used alone.
    • $37
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  • Catalpol
    T27802415-24-9
    Catalpol (Catalpinoside) is an iridoid glycoside with neuroprotective, anti-inflammatory, and anti-hepatitis virus effects.
    • $50
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  • Bifendate
    T327373536-69-3
    Bifendate (Bifendatatum) is commonly used to treat the transaminase elevation that caused by viral hepatitis and drug-induced liver injury.
    • $32
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  • Paederoside
    T3S087220547-45-9
    1. Paederoside is a potent deterrent against the beetle was isolated from the aphid . 2. Paederoside displays high anti-tumor promoting activity against the Epstein-Barr virus activation.
    • $130
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  • Tenofovir Disoproxil Fumarate
    T2409L202138-50-9
    Tenofovir Disoproxil Fumarate (GS-1278 Disoproxil Fumarate) is a pro-drug, fumaric acid salt form of tenofovir, a nucleoside reverse transcriptase inhibitor analog of adenosine. Tenofovir disoproxil fumarate is prescribed to treat HIV and chronic hepatitis B virus (HBV) in adults.
    • $46
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  • Thiamine hydrochloride
    T089467-03-8
    Thiamine hydrochloride (Vitamin B1) is the hydrochloride salt form of thiamine, a vitamin essential for aerobic metabolism, cell growth, transmission of nerve impulses and acetylcholine synthesis. Upon hydrolysis, Thiamine hydrochloride (Vitamin B1) is phosphorylated by thiamine diphosphokinase to form active thiamine pyrophosphate (TPP), also known as cocarboxylase. TPP is a coenzyme for many enzymatic activities involving fatty acid, amino acid and carbohydrate metabolism.
    • $50
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  • RO6889678
    T90541578153-27-1
    RO6889678 is HBV inhibitor with a complex ADME profile.
    • $68
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  • Tivicilovir
    T67813103024-93-7In house
    Tivicilovir (AM188) is a hepatitis B virus inhibitor. tiviclovir is a guanine-related acyclic 2'-deoxyguanine analogue with anti-herpesvirus activity.
    • $138
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  • Metacavir
    T28022120503-45-9
    Metacavir (PNA) is a novel nucleoside reverse transcriptase inhibitor, a deoxyguanosine analog, with anti-hepatitis B virus (HBV) activity and mitochondrial toxicity, which can be used to study HBV infection.
    • $293
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  • DVR-01
    T27221330461-34-2
    DVR-01 is an HBV capsid inhibitor and can be used in studies about the treatment of Hepatitis B virus (HBV) infection and related conditions.
    • $195
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  • Lagociclovir
    T1570492562-88-4In house
    Lagociclovir (MIV-210), a nucleoside analogue, is an antiviral compound available for the treatment of HBV82 that inhibits the replication of wild-type hepatitis B virus (HBV) in human hepatocellular carcinoma cell lines that permanently express HBV.
    • $310
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  • Antiviral agent
    T67904380458-45-7
    Antiviral agent is thiazolidin-4-one with anti-hepatitis B activity
    • $117
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  • DDG-39
    T67797119555-47-4In house
    DDG-39 (1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine) possesses antiviral activity with potent and selective anti-HIV-1 and HBV activity in cell culture. The average antiviral IC50 is 0.61 μM.
    • $189
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  • Ibandronic acid
    T1599114084-78-5
    Ibandronic acid (Bonviva) is a third-generation amino-bisphosphonate with anti-resorptive and anti-hypercalcemic activities.
    • $50
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  • ccc_R08
    T734402919019-72-8In house
    ccc_R08 is an orally available HBV cccDNA inhibitor that reduces extracellular levels of HBV DNA, HBsAg, and HBeAg in a dose-dependent manner. ccc_R08 is investigational for use in the treatment of HBV infections. ccc_R08 has been shown to be effective in the treatment of hepatitis C virus (HCV).
    • $293
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  • Ibandronate sodium
    T1599L138844-81-2
    Ibandronate sodium (Boniva) is a synthetic nitrogen-containing bisphosphonate, used for the treatment of osteoporosis.
    • $76
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  • Besifovir PM
    T67817 In house
    Besifovir PM (LB80331 PM) is an analogue of Besifovir, a novel orally available acyclic nucleotide phosphonate for the treatment of chronic hepatitis B infection.
    • $197
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  • Burfiralimab
    T769372460809-80-5
    Burfiralimab (hzVSF-v13) is a monoclonal immunoglobulin (IgG4) directed against waveform proteins that has anti-HBV effects and can be used to study rheumatoid arthritis,
    • $197
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  • Isothiafludine
    T27634960527-22-4In house
    Isothiafludine (NZ-4) is an orally active anti-HBV compound that acts by blocking the encapsulation of pre-genomic RNA (pgRNA) and interfering with nucleosome capsid assembly, and is used in the study of HBV infections.
    • $293 TargetMol
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  • Linvencorvir
    T642211808248-05-6In house
    Linvencorvir is a hepatitis B virus (HBV) core protein variant modifier used to treat chronic HBV infection.
    • $121
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  • Selgantolimod
    T168702004677-13-6In house
    Selgantolimod is an effective and selective toll-like receptor 8 agonists for the treatment of the hepatitis B virus and human immunodeficiency virus infection.
    • $1,820
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  • ß-Thujaplicinol
    T288594356-35-8In house
    ß-Thujaplicinol, a hydroxylated thujaplicinone isolated from western red cedar heartwood, has antiviral activity, inhibits hepatitis B virus replication by blocking viral ribonuclease H activity, and can be used in the study of viral infections.
    • $293
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  • Tenofovir amibufenamide
    T390431571076-26-0In house
    Tenofovir amibufenamide (HS-10234) is a Tenofovir prodrug, an antiviral compound with oral activity. Tenofovir amibufenamide inhibits hepatitis B virus (HBV) and can be used in chronic hepatitis B (CHB) studies.
    • $293
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  • Helioxanthin derivative 5-4-2
    T11550203935-39-1In house
    Helioxanthin derivative 5-4-2 (Helioxanthin 5-4-2) is an analogue of helioxanthin that shows anti-HBV activity in vitro and can be used to study HBV.
    • $350 TargetMol
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  • Risedronate Sodium
    T1041115436-72-1
    Risedronate Sodium (NE 58095 Sodium) is an aminobisphosphonate derivative of etidronic acid and CALCIUM CHANNEL BLOCKER that inhibits BONE RESORPTION and is used for the treatment of OSTEOPOROSIS.
    • $30
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  • Adefovir dipivoxil
    T1675142340-99-6
    Adefovir dipivoxil (GS 0840) is a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity against hepatitis B virus (HBV), herpes virus, and human immunodeficiency virus (HIV).
    • $31
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  • Osalmid
    T0353526-18-1
    Osalmid (Oxaphenamide) is a choleretic drug, inhibits ribonucleotide reductase activity by targeting ribonucleotide reductase small subunit M2 (RRM2).
    • $34
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  • JNJ-632
    T44751572510-42-9
    JNJ-632 is a hepatitis B virus (HBV) capsid assembly modulator.
    • $30
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  • Isochlorogenic acid A
    T50982450-53-5
    Isochlorogenic acid A (3,5-Dicaffeoylquinic acid), a natural phenolic acid, exhibits antioxidant and anti-inflammatory properties.
    • $59
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  • Osthole
    T2848484-12-8
    Osthole (Osthol), a potential inhibitor of histamine H1 receptor, has been shown to stimulate osteoblast proliferation and differentiation.
    • $31
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  • Punicalagin
    T392165995-63-3
    Punicalagin is a major ellagitannin found in pomegranates that is reported to produce antioxidant, anti-inflammatory, and anticancer effects. It has been shown to prevent high-fat diet-induced obesity-associated accumulation of cardiac triglyceride and ch
    • $130
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  • Tenofovir Disoproxil
    T7111201341-05-1
    Tenofovir Disoproxil (GS 4331) is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B.
    • $41
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  • Oxethazaine
    T0044126-27-2
    Oxethazaine (Oxetacaine), a topical anesthetic, is used to prevent acid-induced esophageal pain.
    • $41
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  • Punicalin
    T4S171865995-64-4
    Punicalin exerts anti-inflammatory, antioxidative, and anti-hepatotoxic activities, it shows inhibitory activity on HIV-1 reverse transcriptase in a dose-dependent manner, with an IC50 of 0.11 microg/ml (0.14 microM).
    • $43
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  • Bicyclol
    T4121118159-48-1
    Bicyclol (SY801)(SY 801) is an anti-hepatitis drug. Oral administration of bicyclol normalizes the elevated serum transaminases (ALT, AST) by 50% in chronic viral hepatitis B and C, and also has a certain level of inhibiting HBV and HCV replication. In combination therapy of bicyclol with interferon alpha, lamivudine and adefovir dipivoxil in HBV or HCV, bicyclol may reduce YMDD mutant and side effects and increase the anti-viral efficacy.
    • $57
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  • RO8191
    T22142691868-88-9
    RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.
    • $38
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  • Bay 41-4109
    T10480L298708-81-3
    BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV)(IC50 : 53 nM).
    • $386
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  • Entecavir
    T0085L142217-69-4
    Entecavir (SQ34676) is a guanosine nucleoside analogue used in the treatment of chronic hepatitis B virus (HBV) infection. Entecavir therapy can be associated with flares of the underlying hepatitis B during or after therapy, but has not been linked to cases of clinically apparent liver injury.
    • $43
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  • Kurarinol
    TN1840855746-98-4
    Kurarinol is a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. Kurarinol has extremely strong tyrosinase inhibitory activity, exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, is a candidate as skin-whitening agents.
    • $2,320
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  • Oxynitidine
    T80649548-31-2
    Oxynitidine, an HBV inhibitor (ID50 = 30.8 µg/mL), effectively suppresses HBV DNA replication and may be utilized in viral infection research [1].
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  • Tobevibart
    T809702645440-65-7
    Tobevibart, an IgG1-lambda humanized monoclonal antibody targeting the hepatitis B virus (HBV) surface envelope protein, exhibits antiviral activity [1].
    • $195
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  • Periglaucine A
    TN47501025023-04-4
    Periglaucine A inhibits hepatitis B virus (HBV) surface antigen (HBsAg) secretion in Hep G2.2.15 cells.
    • $660
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  • Oleana-2,12-dien-28-oic acid
    T67868272108-04-0
    Oleana-2,12-dien-28-oic acid is an HBsAg and HBeAg inhibitor that obviously inhibit HBV deoxyribonucleic acid (HBV-DNA) replication in HepG2.2.15 cells. Oleana-2,12-dien-28-oic acid for the study of hepatitis B virus infection.
    • $195
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  • Swertianolin
    T5S225423445-00-3
    1. Swertianolin (Bellidifolin-8-O-Glucoside), mangiferin, rhodenthoside A-C, isoorientin, isovitexin, and amarogentin would serve as potential chemotaxonomic markers to differentiate Gentianaceae species. 2. Swertianolin and swertiamarin show significant hepatoprotective effect in the liver damage model induced by alpha-naphthylisot hiocyanate. 3. Swertianolin shows anti-acetylcholinesterase activity effects. 4. Swertianolin shows that it can scavenge superoxide and hydroxyl radicals with the studying method of the autoxidation of Pyrogallol and afenton.
    • $89
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  • HBV-IN-37
    T77714380483-01-2
    HBV-IN-37 is an HBV inhibitor with an EC50 value of 10 μM and can be used for hepatitis B disease-related research.
    • $64
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  • Sophoranol
    TN22203411-37-8
    (+)-Sophoranol exhibits antiviral activity against the Coxsackie virus B3. It also shows potent anti-HBV activity with an inhibitory potency against HBsAg secretion and against HBeAg secretion.
    • $700
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  • Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside
    T799751252572-36-3
    Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside (Compound 1), a lignan with anti-HBV activity, exhibits selectivity by targeting the HBV surface antigen (HBsAg) with an IC50 of 0.58 mM, whereas its activity against the HBV e antigen (HBeAg) is significantly lower, with an IC50 of >2.4 mM. This compound is isolable from the plant star anise [1].
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  • HBV-IN-38
    T798791834483-86-1
    HBV-IN-38 (Example 193), an HBV DNA inhibitor with an EC50 value of ≤100 nM, serves as a research tool for investigating viral infections [1].
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