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Anti-SREBP1 Polyclonal Antibody
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Catalog No. TMAB-01774
Alias Sterol regulatory element-binding transcription factor 1, Sterol regulatory element-binding protein 1, Sterol Regulatory Element Binding Transcription Factor 1/Protein 1, Sterol regulatory element binding transcription factor 1, Sterol regulatory element binding protein 1, SREBP-1, SREBP1, SREBP 1c, SREBP 1, SREBF1, SREBF 1, SRBP1, Processed sterol regulatory element-binding protein 1, D630008H06, Class D basic helix-loop-helix protein 1, bHLHd1, BHLHD1, ADD 1
Anti-SREBP1 Polyclonal Antibody is a Rabbit antibody targeting SREBP1. Anti-SREBP1 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Anti-SREBP1 Polyclonal Antibody
Anti-SREBP1 Polyclonal Antibody
😃Good
Catalog No. TMAB-01774Alias Sterol regulatory element-binding transcription factor 1, Sterol regulatory element-binding protein 1, Sterol Regulatory Element Binding Transcription Factor 1/Protein 1, Sterol regulatory element binding transcription factor 1, Sterol regulatory element binding protein 1, SREBP-1, SREBP1, SREBP 1c, SREBP 1, SREBF1, SREBF 1, SRBP1, Processed sterol regulatory element-binding protein 1, D630008H06, Class D basic helix-loop-helix protein 1, bHLHd1, BHLHD1, ADD 1
Anti-SREBP1 Polyclonal Antibody is a Rabbit antibody targeting SREBP1. Anti-SREBP1 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $220 | 7-10 days | |
| 100 μL | $373 | 7-10 days | |
| 200 μL | $527 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-SREBP1 Polyclonal Antibody is a Rabbit antibody targeting SREBP1. Anti-SREBP1 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF. |
| Alias | Sterol regulatory element-binding transcription factor 1, Sterol regulatory element-binding protein 1, Sterol Regulatory Element Binding Transcription Factor 1/Protein 1, Sterol regulatory element binding transcription factor 1, Sterol regulatory element binding protein 1, SREBP-1, SREBP1, SREBP 1c, SREBP 1, SREBF1, SREBF 1, SRBP1, Processed sterol regulatory element-binding protein 1, D630008H06, Class D basic helix-loop-helix protein 1, bHLHd1, BHLHD1, ADD 1 |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Chicken,Sheep) |
| Verified Activity | 1. Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (SREBP-1) Polyclonal Antibody, Unconjugated (TMAB-01774) at 1:200 overnight at 4°C, followed by a conjugated secondary for 20 min and DAB staining. 2. Paraformaldehyde-fixed, paraffin embedded (human colon carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (SREBP-1) Polyclonal Antibody, Unconjugated (TMAB-01774) at 1:200 overnight at 4°C, followed by a conjugated secondary for 20 min and DAB staining. 3. Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (SREBP1) Polyclonal Antibody, Unconjugated (TMAB-01774) at 1:200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining. 4. Paraformaldehyde-fixed, paraffin embedded (mouse liver); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (SREBP1) Polyclonal Antibody, Unconjugated (TMAB-01774) at 1:200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining. 5. Sample: MCF-7 (Human) Cell Lysate at 30 μg A549 (Human) Cell Lysate at 30 μg Hela (Human) Cell Lysate at 30 μg SH-SY5Y (Human) Cell Lysate at 30 μg U87Mg (Human) Cell Lysate at 30 μg A431 (Human) Cell Lysate at 30 μg Primary: Anti-SREBP1 (TMAB-01774) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 54/126 kDa Observed band size: 124 kDa 6. Paraformaldehyde-fixed, paraffin embedded (rat adrenal gland); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (SREBP1) Polyclonal Antibody, Unconjugated (TMAB-01774) at 1:400 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining. |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols. Processed sterol regulatory element-binding protein 1: Nucleus. Isoform SREBP-1aDelta: Nucleus. Isoform SREBP-1cDelta: Nucleus. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Research Background | This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Immunogen | KLH conjugated synthetic peptide: human SREBP-1 |
| Antigen Species | Human |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Metabolism of lipids and lipoproteins,Cholesterol Metabolism,HLH / Leucine Zipper,HLH / Leucine Zipper,Cholesterol Metabolism,Lipid metabolism,Cancer,Obesity |
| Molecular Weight | Theoretical: 54/126 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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