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Anti-ITGAV Polyclonal Antibody 3
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Catalog No. TMAB-07831
Anti-ITGAV Polyclonal Antibody 3 is a Rabbit antibody targeting ITGAV. Anti-ITGAV Polyclonal Antibody 3 can be used in IHC-P,IHC-Fr,IF.
Anti-ITGAV Polyclonal Antibody 3
Anti-ITGAV Polyclonal Antibody 3
😃Good
Catalog No. TMAB-07831
Anti-ITGAV Polyclonal Antibody 3 is a Rabbit antibody targeting ITGAV. Anti-ITGAV Polyclonal Antibody 3 can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-ITGAV Polyclonal Antibody 3 is a Rabbit antibody targeting ITGAV. Anti-ITGAV Polyclonal Antibody 3 can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Human,Rat (predicted:Mouse) |
| Application | |
| Recommended Dose | IHC-P: 1:500-2000; IHC-Fr: 1:500-2000; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell Membrane |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metatastatic diffusion of tumour cells. ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; ITGB1, ITGB3, ITGB5, ITGB6, and ITGB8), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. |
| Immunogen | KLH conjugated synthetic peptide: mouse Integrin alpha-V light chain |
| Antigen Species | Mouse |
| Gene Name | ITGAV |
| Gene ID | |
| Protein Name | Integrin alpha-V |
| Function | The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. |
| Molecular Weight | Theoretical: 18/113 kDa. Actual: 24/125 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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