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VK3-OCH3

Name: VK3-OCH3
Brand: TargetMol
SKU: T3459
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3459Cas No. 255906-59-3

Alias 2-[(2-Methoxy)ethylthio]-3-methyl-1,4-na

VK3-OCH3 (2-[(2-Methoxy)ethylthio]-3-methyl-1,4-na) is a selective antitumor agent via heme oxygenase (HO-1) related mechanisms; Vitamine K3 analogue.

VK3-OCH3

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Purity: 99.71%

Catalog No. T3459Alias 2-[(2-Methoxy)ethylthio]-3-methyl-1,4-naCas No. 255906-59-3

VK3-OCH3 (2-[(2-Methoxy)ethylthio]-3-methyl-1,4-na) is a selective antitumor agent via heme oxygenase (HO-1) related mechanisms; Vitamine K3 analogue.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	In Stock	In Stock
5 mg	$85	In Stock	In Stock
10 mg	$119	In Stock	In Stock
25 mg	$211	In Stock	In Stock
50 mg	$313	In Stock	In Stock
100 mg	$447	-	In Stock
200 mg	$632	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.71%

Appearance:Solid

Color:Red

Resource Download

COA LCMS HNMR

Product Introduction

VK3-OCH3 AI Summary

VK3-OCH3 exhibits various bioactivities, including a binding affinity to MKK7 expressed in HEK293 cells with a dissociation constant (Kd) of 14000.0 nM. It shows inhibition of recombinant CDC25A with an IC50 of 5700.0 nM and CDC25B with an IC50 of 6500.0 nM using OMFP as the substrate. The compound demonstrates cytotoxicity against several human cell lines, notably THP1 (IC50 = 2200.0 nM), MONO-MAC-6 (IC50 = 1700.0 nM), HL60 (IC50 = 1600.0 nM), SW982 (IC50 = 9700.0 nM), Jurkat (IC50 = 3200.0 nM), U937 (IC50 = 5300.0 nM), MCF7 (IC50 = 14900.0 nM), LS174T (IC50 = 15700.0 nM), A549 (IC50 = 18600.0 nM), and PBMC (IC50 = 6200.0 nM), as measured by a reduction in cell viability using the CellTiter-Glo luminescent cell viability assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	VK3-OCH3 (2-[(2-Methoxy)ethylthio]-3-methyl-1,4-na) is a selective antitumor agent via heme oxygenase (HO-1) related mechanisms; Vitamine K3 analogue.
Synonyms	2-[(2-Methoxy)ethylthio]-3-methyl-1,4-na

Chemical Properties

Molecular Weight	262.32
Formula	C₁₄H₁₄O₃S
Cas No.	255906-59-3
Smiles	COCCSC1=C(C)C(=O)c2ccccc2C1=O
Relative Density.	1.25 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (95.3 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8121 mL	19.0607 mL	38.1214 mL	190.6069 mL
5 mM	0.7624 mL	3.8121 mL	7.6243 mL	38.1214 mL
10 mM	0.3812 mL	1.9061 mL	3.8121 mL	19.0607 mL
20 mM	0.1906 mL	0.9530 mL	1.9061 mL	9.5303 mL
50 mM	0.0762 mL	0.3812 mL	0.7624 mL	3.8121 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc