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HDAC8-IN-20a

Name: HDAC8-IN-20a
Brand: TargetMol
SKU: T24133
Price: 193 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24133Cas No. 1884231-52-0

Alias HDAC8IN20a, HDAC8 inhibitor-20a, HDAC8 inhibitor 20a, HDAC8 IN 20a

HDAC8-IN-20a (HDAC8 inhibitor-20a) is a potent and selective HDAC8 inhibitor with an IC50 of 27 nM. HDAC8-IN-20a blocks activation of growth receptor survival signals.

HDAC8-IN-20a

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Purity: 99.22%

Catalog No. T24133Alias HDAC8IN20a, HDAC8 inhibitor-20a, HDAC8 inhibitor 20a, HDAC8 IN 20aCas No. 1884231-52-0

HDAC8-IN-20a (HDAC8 inhibitor-20a) is a potent and selective HDAC8 inhibitor with an IC50 of 27 nM. HDAC8-IN-20a blocks activation of growth receptor survival signals.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$193	In Stock	In Stock
5 mg	$471	In Stock	In Stock
10 mg	$650	In Stock	In Stock
25 mg	$969	In Stock	In Stock
50 mg	$1,260	In Stock	In Stock
100 mg	$1,630	In Stock	In Stock
200 mg	$2,180	-	In Stock
1 mL x 10 mM (in DMSO)	$423	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.22%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

HDAC8-IN-20a AI Summary

HDAC8-IN-20a exhibits potent inhibitory activity against both Schistosoma mansoni HDAC8 and human HDAC8 with IC50 values of approximately 268 nM and 24-27 nM, respectively. It shows weaker inhibitory effects on human HDAC1 and HDAC6 with IC50 values of around 12100 nM and 2900 nM, respectively, indicating selectivity for these HDAC isoforms. Additionally, HDAC8-IN-20a demonstrates moderate cytotoxicity against HEK293 cells with a cell viability of 69.1% at 50 µM after 24 hours, and exhibits an IC50 value of 12700 nM against human BE(2)-C cells after 72 hours. Furthermore, it demonstrates the ability to inhibit acid sphingomyelinase in human HuH7 cell lysates with an IC50 value of 10490 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	HDAC8-IN-20a (HDAC8 inhibitor-20a) is a potent and selective HDAC8 inhibitor with an IC50 of 27 nM. HDAC8-IN-20a blocks activation of growth receptor survival signals.
Targets&IC50	HDAC6 (human):2.9 μM, HDAC1 (human):12.1 μM, smHDAC8:268.2 μM, HDAC8 (human):23.9 μM
Synonyms	HDAC8IN20a, HDAC8 inhibitor-20a, HDAC8 inhibitor 20a, HDAC8 IN 20a

Chemical Properties

Molecular Weight	273.28
Formula	C₁₅H₁₅NO₄
Cas No.	1884231-52-0
Smiles	O(CC1=CC=CC=C1)C2=C(OC)C=CC(C(NO)=O)=C2
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (82.33 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6593 mL	18.2963 mL	36.5925 mL	182.9625 mL
5 mM	0.7319 mL	3.6593 mL	7.3185 mL	36.5925 mL
10 mM	0.3659 mL	1.8296 mL	3.6593 mL	18.2963 mL
20 mM	0.1830 mL	0.9148 mL	1.8296 mL	9.1481 mL
50 mM	0.0732 mL	0.3659 mL	0.7319 mL	3.6593 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc