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CNT2 inhibitor-1

Name: CNT2 inhibitor-1
Brand: TargetMol
SKU: T10853
Price: 129 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10853Cas No. 880155-70-4

CNT2 inhibitor-1 is a potent inhibitor of concentrative nucleoside transporter 2 (CNT2) with an IC50 of 640 nM for hCNT2.

CNT2 inhibitor-1

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Purity: 99.54%

Catalog No. T10853Cas No. 880155-70-4

CNT2 inhibitor-1 is a potent inhibitor of concentrative nucleoside transporter 2 (CNT2) with an IC50 of 640 nM for hCNT2.

Pack Size	Price	Availability
1 mg	$129	In Stock
5 mg	$326	In Stock
10 mg	$489	In Stock
25 mg	$883	In Stock
50 mg	$1,320	In Stock
100 mg	$1,920	In Stock
1 mL x 10 mM (in DMSO)	$358	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.54%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	CNT2 inhibitor-1 is a potent inhibitor of concentrative nucleoside transporter 2 (CNT2) with an IC50 of 640 nM for hCNT2.
Targets&IC50	CNT2 (human):640 nM
In vitro	CNT2 inhibitor-1 (compound 48) demonstrates an 81-fold increase in inhibitory activity compared to the parent compound 12, and a 1500-fold higher potency than 2’-deoxy-5-fluorouridine, phlorizin, and 7,8,3’-trihydroxyflavone, all recognized hCNT2 inhibitors[1].

Chemical Properties

Molecular Weight	448.47
Formula	C₂₃H₂₄N₆O₄
Cas No.	880155-70-4
Smiles	Nc1ncnc2n([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c(NCc3ccc(cc3)-c3ccccc3)nc12
Relative Density.	1.57 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (100.34 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2298 mL	11.1490 mL	22.2980 mL	111.4902 mL
5 mM	0.4460 mL	2.2298 mL	4.4596 mL	22.2980 mL
10 mM	0.2230 mL	1.1149 mL	2.2298 mL	11.1490 mL
20 mM	0.1115 mL	0.5575 mL	1.1149 mL	5.5745 mL
50 mM	0.0446 mL	0.2230 mL	0.4460 mL	2.2298 mL
100 mM	0.0223 mL	0.1115 mL	0.2230 mL	1.1149 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc