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Walrycin B

Name: Walrycin B
Brand: TargetMol
SKU: T1832
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1832Cas No. 878419-78-4

Walrycin B is a new-type antibacterial compound targeting the WalR response regulator.

Walrycin B

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🥰Excellent

Purity: 98%

Catalog No. T1832Cas No. 878419-78-4

Walrycin B is a new-type antibacterial compound targeting the WalR response regulator.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$48	In Stock	In Stock
10 mg	$73	In Stock	In Stock
25 mg	$118	In Stock	In Stock
50 mg	$178	In Stock	In Stock
100 mg	$248	In Stock	In Stock
200 mg	$359	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98%

Color:Yellow

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Product Introduction

Walrycin B AI Summary

Walrycin B demonstrates multifaceted bioactivities, including a half-life of 2.333 hours in rat liver microsomes at 3 µM and high metabolic stability with 105.0% activity recovery after 45 minutes in the same microsomes without NADPH. It inhibits several enzymes: TDP1 (less than 30.0% inhibition), APE-1 (IC50 > 200,000 nM), and TDP2 (Imax of 75.0%, EC50 of 330.0 nM). It potently inhibits Lipoamide Dehydrogenase (Lpd) with an IC50 < 40.0 nM and Mtb PDH with a similar IC50. Walrycin B shows antiviral activity against SARS-CoV-2, reducing cytotoxicity in Caco-2 and VERO-6 cells at 10 µM concentrations, albeit with low inhibition percentages (-1.14% to -0.33%). It also inhibits SARS-CoV-2 3CL-Pro protease at 20 µM (3.16% and 14.84% inhibition), with an IC50 of 260.0 nM using a fluorogenic peptide substrate. Additionally, Walrycin B inhibits human HDAC6 with 12.3% inhibition using a commercial substrate and 82.78% with a custom peptide substrate. It shows cytotoxicity against Vero E6 cells (CC50 of 4250.0 nM) and HepG2 cells (IC50 of 1100.0 nM), and it demonstrates antiviral efficacy against SARS-CoV-2 infected Vero E6 cells (EC50 of 3550.0 nM) while inhibiting SARS-CoV-2 Main protease (IC50 of 260.0 nM)..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Walrycin B is a new-type antibacterial compound targeting the WalR response regulator.
Targets&IC50	Antibacterial:0.39 ug/ml

Chemical Properties

Molecular Weight	337.26
Formula	C₁₄H₁₀F₃N₅O₂
Cas No.	878419-78-4
Smiles	Cn1nc(nc2c1nc(=O)n(C)c2=O)-c1ccc(cc1)C(F)(F)F
Relative Density.	1.56 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (148.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (7.41 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9651 mL	14.8254 mL	29.6507 mL	148.2536 mL
5 mM	0.5930 mL	2.9651 mL	5.9301 mL	29.6507 mL
10 mM	0.2965 mL	1.4825 mL	2.9651 mL	14.8254 mL
20 mM	0.1483 mL	0.7413 mL	1.4825 mL	7.4127 mL
50 mM	0.0593 mL	0.2965 mL	0.5930 mL	2.9651 mL
100 mM	0.0297 mL	0.1483 mL	0.2965 mL	1.4825 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc