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medicagenic acid

Name: medicagenic acid
Brand: TargetMol
SKU: T8167
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8167Cas No. 599-07-5

Alias Castanogenin

Medicagenic acid (Castanogenin), isolated from the roots of Herniaria glabra L, exhibits potent fungistatic effects against several plant pathogens and human dermatophytes.

medicagenic acid

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Purity: 99.84%

Catalog No. T8167Alias CastanogeninCas No. 599-07-5

Medicagenic acid (Castanogenin), isolated from the roots of Herniaria glabra L, exhibits potent fungistatic effects against several plant pathogens and human dermatophytes.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$43	In Stock	In Stock
5 mg	$94	In Stock	In Stock
10 mg	$137	In Stock	In Stock
25 mg	$226	In Stock	In Stock
50 mg	$335	-	In Stock
100 mg	$497	-	In Stock
1 mL x 10 mM (in DMSO)	$150	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.84%

Color:White

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Product Introduction

medicagenic acid AI Summary

medicagenic acid exhibits growth inhibition activities against a variety of human tumor cell lines, including breast, renal, non-small cell lung, leukemia, prostate, melanoma, ovarian, central nervous system, and colon cell lines, with a GI50 value of 100,000.0 nM indicating strong cytotoxic effects. It shows more potent activity against certain leukemia cell lines such as HL-60(TB) with a GI50 of 31,622.78 nM and K-562 with a GI50 of 78,342.96 nM, suggesting potential as an anti-cancer agent. The compound also inhibits enzymes in the arachidonic acid pathway, showing full inhibition of N-terminal His-tagged 15-LOX2 and COX1, while exhibiting weaker inhibition of COX2 (IC50 > 40,000.0 nM). Additionally, medicagenic acid demonstrates neuroprotective activity against H2O2-induced cell death in human SH-SY5Y cells, with cell viability percentages of 60.14%, 61.12%, and 62.16% at concentrations of 25 µM, 50 µM, and 100 µM respectively, indicating a dose-dependent neuroprotective effect..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Medicagenic acid (Castanogenin), isolated from the roots of Herniaria glabra L, exhibits potent fungistatic effects against several plant pathogens and human dermatophytes.
Synonyms	Castanogenin

Chemical Properties

Molecular Weight	502.68
Formula	C₃₀H₄₆O₆
Cas No.	599-07-5
Smiles	[H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)C2=CC[C@]2([H])[C@@]3(C)C[C@H](O)[C@H](O)[C@@](C)(C(O)=O)[C@]3([H])CC[C@@]12C)C(O)=O
Relative Density.	1.23g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (298.4 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9893 mL	9.9467 mL	19.8934 mL	99.4669 mL
5 mM	0.3979 mL	1.9893 mL	3.9787 mL	19.8934 mL
10 mM	0.1989 mL	0.9947 mL	1.9893 mL	9.9467 mL
20 mM	0.0995 mL	0.4973 mL	0.9947 mL	4.9733 mL
50 mM	0.0398 mL	0.1989 mL	0.3979 mL	1.9893 mL
100 mM	0.0199 mL	0.0995 mL	0.1989 mL	0.9947 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc