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Anti-INPP5D Antibody (6F813)
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Catalog No. TMAH-00634
Alias SIP-145, SHIP-1, SHIP1, SHIP, SH2 domain-containing inositol phosphatase 1, SH2 domain-containing inositol 5'-phosphatase 1, Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1, p150Ship, Inositol polyphosphate-5-phosphatase of 145 kDa, hp51CN, EC 3.1.3.86
Anti-INPP5D Antibody (6F813) is an antibody targeting INPP5D. Anti-INPP5D Antibody (6F813) can be used in ELISA, WB, IHC, IP.
Anti-INPP5D Antibody (6F813)
Anti-INPP5D Antibody (6F813)
😃Good
Catalog No. TMAH-00634Alias SIP-145, SHIP-1, SHIP1, SHIP, SH2 domain-containing inositol phosphatase 1, SH2 domain-containing inositol 5'-phosphatase 1, Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1, p150Ship, Inositol polyphosphate-5-phosphatase of 145 kDa, hp51CN, EC 3.1.3.86
Anti-INPP5D Antibody (6F813) is an antibody targeting INPP5D. Anti-INPP5D Antibody (6F813) can be used in ELISA, WB, IHC, IP.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $209 | 7-10 days | |
| 100 μL | $347 | 7-10 days |
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Chemical Properties
| Description | Anti-INPP5D Antibody (6F813) is an antibody targeting INPP5D. Anti-INPP5D Antibody (6F813) can be used in ELISA, WB, IHC, IP. |
| Alias | SIP-145, SHIP-1, SHIP1, SHIP, SH2 domain-containing inositol phosphatase 1, SH2 domain-containing inositol 5'-phosphatase 1, Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1, p150Ship, Inositol polyphosphate-5-phosphatase of 145 kDa, hp51CN, EC 3.1.3.86 |
| Ig Type | Rabbit IgG |
| Clone | 6F813 |
| Reactivity | Human |
| Verified Activity | 1. Western Blot -Positive WB detected in: Raji whole cell lysate, K562 whole cell lysate -All lanes: INPP5D antibody at 1:1500 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 134, 110 kDa -Observed band size: 145 kDa 2. IHC image of TMAH-00634 diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. 3. Immunoprecipitating SHIP in Raji whole cell lysate -Lane 1: Rabbit control IgG instead of TMAH-00634 in Raji whole cell lysate. For western blotting,a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000) -Lane 2: TMAH-00634(2µg)+ Raji whole cell lysate(500µg) -Lane 3: Raji whole cell lysate (10µg) |
| Application | ELISA, WB, IHC, IP |
| Recommended Dose | WB:1:500-1:5000; IHC:1:50-1:200; IP:1:200-1:1000. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cytoplasm. Cell membrane; Peripheral membrane protein. Membrane raft. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human SHIP |
| Antigen Species | Human |
| Gene ID | 3635 |
| Uniprot ID | |
| Biology Area | Immunology, Signal transduction |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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