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Propargyl-PEG5-amine
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Catalog No. T16636Cas No. 1589522-46-2
Propargyl-PEG5-amine is a non-cleavable linker compound used extensively in the synthesis of antibody–drug conjugates (ADCs) and PROTACs, and Propargyl-PEG5-amine functions as a PEG-based connector that facilitates stable conjugation between molecular components. Propargyl-PEG5-amine supports modular assembly strategies in targeted therapeutic design by providing a robust, hydrophilic spacer that enhances solubility and structural flexibility during ADC and PROTAC construction, which enables the efficient bio-conjugation workflows in chemical biology and medicinal chemistry research.
Propargyl-PEG5-amine
😃Good
Catalog No. T16636Cas No. 1589522-46-2
Propargyl-PEG5-amine is a non-cleavable linker compound used extensively in the synthesis of antibody–drug conjugates (ADCs) and PROTACs, and Propargyl-PEG5-amine functions as a PEG-based connector that facilitates stable conjugation between molecular components. Propargyl-PEG5-amine supports modular assembly strategies in targeted therapeutic design by providing a robust, hydrophilic spacer that enhances solubility and structural flexibility during ADC and PROTAC construction, which enables the efficient bio-conjugation workflows in chemical biology and medicinal chemistry research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 200 mg | $31 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
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Chemical Properties
| Description | Propargyl-PEG5-amine is a non-cleavable linker compound used extensively in the synthesis of antibody–drug conjugates (ADCs) and PROTACs, and Propargyl-PEG5-amine functions as a PEG-based connector that facilitates stable conjugation between molecular components. Propargyl-PEG5-amine supports modular assembly strategies in targeted therapeutic design by providing a robust, hydrophilic spacer that enhances solubility and structural flexibility during ADC and PROTAC construction, which enables the efficient bio-conjugation workflows in chemical biology and medicinal chemistry research. |
| In vitro | Antibody-drug conjugates (ADCs) consist of an antibody linked to a cytotoxin through an ADC linker. Proteolysis targeting chimeras (PROTACs) include two different ligands connected by a linker: one targets an E3 ubiquitin ligase, and the other targets the protein of interest, leveraging the ubiquitin-proteasome system for selective protein degradation. |
| Molecular Weight | 275.34 |
| Formula | C13H25NO5 |
| Cas No. | 1589522-46-2 |
| Smiles | C#CCOCCOCCOCCOCCOCCN |
| Relative Density. | 1.049 g/cm3 (Predicted) |
| Color | Transparent |
| Appearance | Liquid |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (290.55 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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