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PROTAC IRAK4 degrader-1

Name: PROTAC IRAK4 degrader-1
Brand: TargetMol
SKU: T13842
Price: 471 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13842Cas No. 2360533-90-8

PROTAC IRAK4 degrader-1 (compound I-210) is a Cereblon based PROTAC consisting of the PROTAC IRAK4 ligand-1, the E3 ligase ligand Pomalidomide and the PROTAC linker AM-Imidazole-PA-Boc.

PROTAC IRAK4 degrader-1

🥰Excellent

Purity: 99.76%

Catalog No. T13842Cas No. 2360533-90-8

PROTAC IRAK4 degrader-1 (compound I-210) is a Cereblon based PROTAC consisting of the PROTAC IRAK4 ligand-1, the E3 ligase ligand Pomalidomide and the PROTAC linker AM-Imidazole-PA-Boc.

Pack Size	Price	Availability
1 mg	$471	In Stock
5 mg	$1,038	In Stock
10 mg	$1,618	In Stock
25 mg	$3,196	In Stock
50 mg	$5,146	In Stock

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Purity:99.76%

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COA LCMS HNMR

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Product Introduction

Bioactivity

Description

PROTAC IRAK4 degrader-1 (compound I-210) is a Cereblon based PROTAC consisting of the PROTAC IRAK4 ligand-1, the E3 ligase ligand Pomalidomide and the PROTAC linker AM-Imidazole-PA-Boc.

Chemical Properties

Molecular Weight	904.85
Formula	C₄₄H₃₉F₃N₁₂O₇
Cas No.	2360533-90-8
Smiles	O=C(NC1=CN(N=C1C(F)(F)F)C2=CC=C(C=C2)C(=O)NCCCN3C=NC(=C3)CNC4=CC=CC=5C(=O)N(C(=O)C45)C6C(=O)NC(=O)CC6)C=7N=C(OC7)C=8C=CN=C(C8)NCC9CC9
Relative Density.	1.61 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 160 mg/mL (176.82 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1052 mL	5.5258 mL	11.0516 mL	55.2578 mL
5 mM	0.2210 mL	1.1052 mL	2.2103 mL	11.0516 mL
10 mM	0.1105 mL	0.5526 mL	1.1052 mL	5.5258 mL
20 mM	0.0553 mL	0.2763 mL	0.5526 mL	2.7629 mL
50 mM	0.0221 mL	0.1105 mL	0.2210 mL	1.1052 mL
100 mM	0.0111 mL	0.0553 mL	0.1105 mL	0.5526 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc