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Anti-Leptin Receptor Antibody (1S966)

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Catalog No. TMAB-08281

Anti-Leptin Receptor Antibody (1S966) is a Rabbit antibody targeting Leptin Receptor. Anti-Leptin Receptor Antibody (1S966) can be used in IHC-P,IHC-Fr,IF,WB.

Anti-Leptin Receptor Antibody (1S966)

Anti-Leptin Receptor Antibody (1S966)

😃Good
Catalog No. TMAB-08281
Anti-Leptin Receptor Antibody (1S966) is a Rabbit antibody targeting Leptin Receptor. Anti-Leptin Receptor Antibody (1S966) can be used in IHC-P,IHC-Fr,IF,WB.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 μL$1517-10 days7-10 days
50 μL$2647-10 days7-10 days
100 μL$4707-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-Leptin Receptor Antibody (1S966) is a Rabbit antibody targeting Leptin Receptor. Anti-Leptin Receptor Antibody (1S966) can be used in IHC-P,IHC-Fr,IF,WB.
Ig Type
IgG
Clone
1S966
Reactivity
Human,Mouse,Rat
Application
Recommended Dose
IHC-P: 1:50-200; IHC-Fr: 1:50-200; IF: 1:50-200; WB: 1:500-2000
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationCell membrane; Single-pass type I membrane protein. Isoform E: Secreted (Probable). Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus.
Tissue SpecificityIsoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus.
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Research BackgroundThe protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010]
Antigen Details
Immunogen
A synthesized peptide: human Leptin receptor
Antigen Species
Human
Gene Name
LEPR
Gene ID
Protein Name
Leptin receptor
Uniprot ID
Function
Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity).
Chemical Properties
Molecular WeightTheoretical: 126 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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