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MK-1064

Name: MK-1064
Brand: TargetMol
SKU: T3722
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3722Cas No. 1207253-08-4

Alias Urokinase inhibitor 1, MK 1064

MK-1064 (Urokinase inhibitor 1) is a selective orexin 2 receptor antagonist (2-SORA).

MK-1064

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Purity: 99.82%

Catalog No. T3722Alias Urokinase inhibitor 1, MK 1064Cas No. 1207253-08-4

MK-1064 (Urokinase inhibitor 1) is a selective orexin 2 receptor antagonist (2-SORA).

Pack Size	Price	Availability
1 mg	$48	In Stock
5 mg	$98	In Stock
10 mg	$163	In Stock
25 mg	$293	In Stock
50 mg	$488	In Stock
100 mg	$787	In Stock
1 mL x 10 mM (in DMSO)	$113	In Stock

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Batch Information

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Purity:99.82%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	MK-1064 (Urokinase inhibitor 1) is a selective orexin 2 receptor antagonist (2-SORA).
Targets&IC50	OX1 receptor:1789 nM, OX2 receptor:0.5 nM (Ki), OX2 receptor:18 nM, OX1 receptor:1584 nM (Ki)
Synonyms	Urokinase inhibitor 1, MK 1064

Chemical Properties

Molecular Weight	461.9
Formula	C₂₄H₂₀ClN₅O₃
Cas No.	1207253-08-4
Smiles	COc1ccc(CNC(=O)c2cc(cnc2-c2ccccn2)-c2cncc(Cl)c2)nc1OC
Relative Density.	1.305 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 50 mg/mL (108.25 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1650 mL	10.8249 mL	21.6497 mL	108.2485 mL
5 mM	0.4330 mL	2.1650 mL	4.3299 mL	21.6497 mL
10 mM	0.2165 mL	1.0825 mL	2.1650 mL	10.8249 mL
20 mM	0.1082 mL	0.5412 mL	1.0825 mL	5.4124 mL
50 mM	0.0433 mL	0.2165 mL	0.4330 mL	2.1650 mL
100 mM	0.0216 mL	0.1082 mL	0.2165 mL	1.0825 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc