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7-Methylguanine

Name: 7-Methylguanine
Brand: TargetMol
SKU: T10194
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10194Cas No. 578-76-7

Alias N7-Methylguanine

7-Methylguanine is an orally available PARP1 inhibitor (Ki=61 μM) that competes with the substrate NAD+, exhibiting anticancer activity. As a natural nucleic acid metabolite, it may serve as a probe for protein-DNA interactions.

7-Methylguanine

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Purity: 99.99%

Catalog No. T10194Alias N7-MethylguanineCas No. 578-76-7

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	-	In Stock
50 mg	$40	-	In Stock
100 mg	$57	-	In Stock
500 mg	$135	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.99%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	7-Methylguanine is an orally available PARP1 inhibitor (Ki=61 μM) that competes with the substrate NAD+, exhibiting anticancer activity. As a natural nucleic acid metabolite, it may serve as a probe for protein-DNA interactions.
Targets&IC50	PARP-1:61 μM (Ki)
In vitro	7-Methylguanine (0-200 μM) inhibits the activity of PARP1 enzyme in a dose-dependent manner [1]. 7-Methylguanine is a competitive PARP-1 inhibitor with an inhibition constant (Ki value) of 61 μM [2]. 7-Methylguanine (0-450 μM) suppresses the catalytic activity of PARP-1, thereby preventing the dissociation of the PARP-1-DNA complex [2]. After 24 hours of treatment with 7-Methylguanine (0.02-0.2 mg/mL), no DNA damage was observed in immortalized Homo sapiens renal epithelial cells (NKE-hTERT) [3].
In vivo	In CBA, BALB/c, and C57BL/6 mice, 7-Methylguanine (50 mg/kg, administered orally, three times per week for 4 weeks) did not cause adverse reactions or morphological changes, while it inhibited tumor growth in CBA mice with uterine sarcoma US-322 [3]. In BALB/c mice transplanted with Akatol tumors, 7-Methylguanine (50 mg/kg, administered via gavage, three times per week) effectively penetrated tumor tissues and suppressed the growth of colon adenocarcinoma [5].
Synonyms	N7-Methylguanine

Chemical Properties

Molecular Weight	165.15
Formula	C₆H₇N₅O
Cas No.	578-76-7
Smiles	O=C1N=C(N)NC=2N=CN(C12)C
Relative Density.	1.83g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

1M NaOH: 80 mg/mL (484.41 mM), Sonication is recommended.

H2O: 3.3 mg/mL (19.98 mM), when pH is adjusted to 11 with 1 M NaOH. Sonication is recommended.

Solution Preparation Table

H2O/1M NaOH

	1mg	5mg	10mg	50mg
1 mM	6.0551 mL	30.2755 mL	60.5510 mL	302.7551 mL
5 mM	1.2110 mL	6.0551 mL	12.1102 mL	60.5510 mL
10 mM	0.6055 mL	3.0276 mL	6.0551 mL	30.2755 mL

1M NaOH

	1mg	5mg	10mg	50mg
20 mM	0.3028 mL	1.5138 mL	3.0276 mL	15.1378 mL
50 mM	0.1211 mL	0.6055 mL	1.2110 mL	6.0551 mL
100 mM	0.0606 mL	0.3028 mL	0.6055 mL	3.0276 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc