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PKC-theta inhibitor hcl

Name: PKC-theta inhibitor hcl
Brand: TargetMol
SKU: T5817
Price: 85 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T5817Cas No. 2253640-49-0

PKC-theta inhibitor hcl is a selective PKC-θinhibitor(IC50:12 nM).

PKC-theta inhibitor hcl

🥰Excellent

Purity: 98.93%

Catalog No. T5817Cas No. 2253640-49-0

PKC-theta inhibitor hcl is a selective PKC-θinhibitor(IC50:12 nM).

Pack Size	Price	Availability
1 mg	$85	In Stock
2 mg	$123	In Stock
5 mg	$245	In Stock
10 mg	$396	In Stock
25 mg	$662	In Stock
50 mg	$943	In Stock
100 mg	$1,280	In Stock
500 mg	$2,560	In Stock

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Batch Information

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Purity:98.93%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	PKC-theta inhibitor hcl is a selective PKC-θinhibitor(IC50:12 nM).
Targets&IC50	PKCθ:12 nM

Chemical Properties

Molecular Weight	490.91
Formula	C₂₀H₂₆ClF₃N₆O₃
Cas No.	2253640-49-0
Smiles	Cl.NCC1CCC(CNc2nc(NCc3ccccc3OC(F)(F)F)ncc2[N+]([O-])=O)CC1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (121.04 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0370 mL	10.1852 mL	20.3703 mL	101.8517 mL
5 mM	0.4074 mL	2.0370 mL	4.0741 mL	20.3703 mL
10 mM	0.2037 mL	1.0185 mL	2.0370 mL	10.1852 mL
20 mM	0.1019 mL	0.5093 mL	1.0185 mL	5.0926 mL
50 mM	0.0407 mL	0.2037 mL	0.4074 mL	2.0370 mL
100 mM	0.0204 mL	0.1019 mL	0.2037 mL	1.0185 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc