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Setiptiline maleate

Name: Setiptiline maleate
Brand: TargetMol
SKU: T12900L
Price: 49 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12900LCas No. 85650-57-3

Alias ORG-8282, ORG8282, MOD-20, MOD20, MO-8282, MO8282

Setiptiline maleate is the salt form of Setiptiline.Setiptiline (Org-8282) is a norepinephrine reuptake inhibitor, 2-adrenergic receptor antagonist, H1 receptor inverse agonist, and 5-HT serotonin receptor antagonist with antidepressant activity.

Setiptiline maleate

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Purity: 99.94%

Catalog No. T12900LAlias ORG-8282, ORG8282, MOD-20, MOD20, MO-8282, MO8282Cas No. 85650-57-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	$49	-	In Stock
1 mL x 10 mM (in DMSO)	$49	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.94%

Appearance:Solid

Color:Yellow

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COA

Product Introduction

Bioactivity

Description	Setiptiline maleate is the salt form of Setiptiline.Setiptiline (Org-8282) is a norepinephrine reuptake inhibitor, 2-adrenergic receptor antagonist, H1 receptor inverse agonist, and 5-HT serotonin receptor antagonist with antidepressant activity.
In vitro	Setiptiline maleate weakly inhibits norepinephrine reuptake in rat brain synaptosomes, thereby enhancing noradrenergic neurotransmission.[1] In rat brain membrane preparations, Setiptiline maleate blocks presynaptic α2-adrenergic receptors, which facilitates the increased release of norepinephrine and serotonin.[2] In HEK293 cells expressing human 5-HT2A receptors, setiptiline inhibited serotonin-induced calcium influx in a dose-dependent manner.[3]
In vivo	Setiptiline maleate mildly increased spontaneous motor activity and ambulation in rats (open field test), and enhanced the locomotor stimulation induced by methamphetamine. Setiptiline maleate significantly reduced immobility time in the forced swim test in rats, indicating antidepressant-like properties. Setiptiline maleate inhibited haloperidol-induced catalepsy, physostigmine-induced yawning, 5-HTP + Ro4-4602-induced body shaking and head twitch, and morphine withdrawal-induced body shaking. [4]
Synonyms	ORG-8282, ORG8282, MOD-20, MOD20, MO-8282, MO8282

Chemical Properties

Molecular Weight	377.43
Formula	C₂₃H₂₃NO₄
Cas No.	85650-57-3
Smiles	C(=C\C(O)=O)\C(O)=O.CN1CC2=C(C=3C(CC=4C2=CC=CC4)=CC=CC3)CC1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (211.96 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6495 mL	13.2475 mL	26.4950 mL	132.4749 mL
5 mM	0.5299 mL	2.6495 mL	5.2990 mL	26.4950 mL
10 mM	0.2649 mL	1.3247 mL	2.6495 mL	13.2475 mL
20 mM	0.1325 mL	0.6624 mL	1.3247 mL	6.6237 mL
50 mM	0.0530 mL	0.2649 mL	0.5299 mL	2.6495 mL
100 mM	0.0265 mL	0.1325 mL	0.2649 mL	1.3247 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc