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Setiptiline maleate
🥰Excellent
Catalog No. T12900LCas No. 85650-57-3
Alias ORG-8282, ORG8282, MOD-20, MOD20, MO-8282, MO8282
Setiptiline maleate is the salt form of Setiptiline.Setiptiline (Org-8282) is a norepinephrine reuptake inhibitor, 2-adrenergic receptor antagonist, H1 receptor inverse agonist, and 5-HT serotonin receptor antagonist with antidepressant activity.
Setiptiline maleate
🥰Excellent
Purity: 99.94%
Catalog No. T12900LAlias ORG-8282, ORG8282, MOD-20, MOD20, MO-8282, MO8282Cas No. 85650-57-3
Setiptiline maleate is the salt form of Setiptiline.Setiptiline (Org-8282) is a norepinephrine reuptake inhibitor, 2-adrenergic receptor antagonist, H1 receptor inverse agonist, and 5-HT serotonin receptor antagonist with antidepressant activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $46 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $85 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Setiptiline maleate is the salt form of Setiptiline.Setiptiline (Org-8282) is a norepinephrine reuptake inhibitor, 2-adrenergic receptor antagonist, H1 receptor inverse agonist, and 5-HT serotonin receptor antagonist with antidepressant activity. |
| In vitro | Setiptiline maleate weakly inhibits norepinephrine reuptake in rat brain synaptosomes, thereby enhancing noradrenergic neurotransmission.[1] In rat brain membrane preparations, Setiptiline maleate blocks presynaptic α2-adrenergic receptors, which facilitates the increased release of norepinephrine and serotonin.[2] In HEK293 cells expressing human 5-HT2A receptors, setiptiline inhibited serotonin-induced calcium influx in a dose-dependent manner.[3] |
| In vivo | Setiptiline maleate mildly increased spontaneous motor activity and ambulation in rats (open field test), and enhanced the locomotor stimulation induced by methamphetamine. Setiptiline maleate significantly reduced immobility time in the forced swim test in rats, indicating antidepressant-like properties. Setiptiline maleate inhibited haloperidol-induced catalepsy, physostigmine-induced yawning, 5-HTP + Ro4-4602-induced body shaking and head twitch, and morphine withdrawal-induced body shaking. [4] |
| Alias | ORG-8282, ORG8282, MOD-20, MOD20, MO-8282, MO8282 |
| Molecular Weight | 377.43 |
| Formula | C23H23NO4 |
| Cas No. | 85650-57-3 |
| Smiles | C(=C\C(O)=O)\C(O)=O.CN1CC2=C(C=3C(CC=4C2=CC=CC4)=CC=CC3)CC1 |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (211.96 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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