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Dual Galectin-3/EGFR-IN-1

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Catalog No. T204936

Dual Galectin-3/EGFR-IN-1 (Compound 29) is a dual inhibitor targeting Galectin-3 and EGFR, with dissociation constants (KD) of 52.29 μM and 3.31 μM, respectively. It inhibits TGF-β-induced hepatic stellate cell (HSC) activation, induces apoptosis in LX-2 cells, and shows antifibrotic activity in the liver.

Dual Galectin-3/EGFR-IN-1

Dual Galectin-3/EGFR-IN-1

😃Good
Catalog No. T204936
Dual Galectin-3/EGFR-IN-1 (Compound 29) is a dual inhibitor targeting Galectin-3 and EGFR, with dissociation constants (KD) of 52.29 μM and 3.31 μM, respectively. It inhibits TGF-β-induced hepatic stellate cell (HSC) activation, induces apoptosis in LX-2 cells, and shows antifibrotic activity in the liver.
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Product Introduction

Bioactivity
Description
Dual Galectin-3/EGFR-IN-1 (Compound 29) is a dual inhibitor targeting Galectin-3 and EGFR, with dissociation constants (KD) of 52.29 μM and 3.31 μM, respectively. It inhibits TGF-β-induced hepatic stellate cell (HSC) activation, induces apoptosis in LX-2 cells, and shows antifibrotic activity in the liver.
Targets&IC50
EGFR:3.31 μM(Kd)
Chemical Properties
Molecular Weight683.709
FormulaC32H41N7O10
SmilesCC(=O)NC1C(C(C(OC1OCCN2C=C(N=N2)C3=CC(=CC=C3)NC4=NC=NC5=CC(=C(C=C54)OCCOC)OCCOC)CO)O)O
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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