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Givinostat hydrochloride

Name: Givinostat hydrochloride
Brand: TargetMol
SKU: T6279L
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6279LCas No. 199657-29-9

Alias ITF2357 hydrochloride, ITF-2357 HCl, ITF2357 HCl, ITF 2357 HCl, Givinostat HCl

Givinostat hydrochloride (ITF2357 hydrochloride) is an inhibitor of HDAC with IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat hydrochloride exhibits anti-inflammatory, anti-angiogenic, and antineoplastic activities.

Givinostat hydrochloride

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Purity: 99.39%

Catalog No. T6279LAlias ITF2357 hydrochloride, ITF-2357 HCl, ITF2357 HCl, ITF 2357 HCl, Givinostat HClCas No. 199657-29-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	In Stock	In Stock
5 mg	$73	In Stock	In Stock
10 mg	$129	In Stock	In Stock
25 mg	$267	In Stock	In Stock
50 mg	$463	In Stock	In Stock
100 mg	$737	-	In Stock
200 mg	$987	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$74	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.39%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Givinostat hydrochloride (ITF2357 hydrochloride) is an inhibitor of HDAC with IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat hydrochloride exhibits anti-inflammatory, anti-angiogenic, and antineoplastic activities.
Targets&IC50	HDAC3 (human):157 nM (IC50), HD2:10 nM (IC50), HDAC6 (human):315 nM (IC50), HD1-B:7.5 nM (IC50), HDAC10 (human):340 nM (IC50), HDAC2 (human):325 nM (IC50), HDAC7 (human):524 nM (IC50), HDAC4 (human):1059 nM (IC50), HD1-A:16 nM (IC50), HDAC11 (human):292 nM (IC50), HDAC9 (human):541 nM (IC50), HDAC1 (human):198 nM (IC50), HDAC8 (human):854 nM (IC50), HDAC5 (human):532 nM (IC50)
In vitro	Givinostat hydrochloride inhibits JS-1 cell proliferation in a concentration-dependent manner. Givinostat hydrochloride (≥500 nM) is associated with significant inhibition of JS-1 cell proliferation. Also, the cell inhibition rate significantly differs between the group cotreated with Givinostat hydrochloride ≥250 nM plus LPS and the group without LPS treatment[3]. Givinostat hydrochloride (25, 50, and 100 nM) reduces IL-1β secretion more than 70%. Givinostat hydrochloride suppresses the production of IL-6 in PBMCs stimulated with TLR agonists as well as the combination of IL-12 plus IL-18. IL-6 secretion decreases to 50% at 50 nM, but at 100 and 200 nM, there is no reduction[4].
In vivo	Givinostat hydrochloride (10 mg/kg) reduces serum TNFα by 60%. Pretreatment of Givinostat hydrochloride (0.1 mg/kg) significantly reduces the circulating TNFα by nearly 90%[4].
Synonyms	ITF2357 hydrochloride, ITF-2357 HCl, ITF2357 HCl, ITF 2357 HCl, Givinostat HCl

Chemical Properties

Molecular Weight	457.95
Formula	C₂₄H₂₈ClN₃O₄
Cas No.	199657-29-9
Smiles	Cl.CCN(CC)Cc1ccc2cc(COC(=O)Nc3ccc(cc3)C(=O)NO)ccc2c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 245 mg/mL (534.99 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1836 mL	10.9182 mL	21.8364 mL	109.1822 mL
5 mM	0.4367 mL	2.1836 mL	4.3673 mL	21.8364 mL
10 mM	0.2184 mL	1.0918 mL	2.1836 mL	10.9182 mL
20 mM	0.1092 mL	0.5459 mL	1.0918 mL	5.4591 mL
50 mM	0.0437 mL	0.2184 mL	0.4367 mL	2.1836 mL
100 mM	0.0218 mL	0.1092 mL	0.2184 mL	1.0918 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc