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Pharmacokinetics (PK)

ADME profiles defined.In vivo drug behavior quantified.

Inquiry

Combining the advantages of the affinity database - PDBbind+ database

Advanced testing equipment

High-level mass spectrometry detection equipment

Strict experimental standards

Standardize the management of animal growth environments

Professional technical team

Possesses extensive experience in pharmacokinetic testing

High-quality service level

Efficient and high-quality delivery of results

Pharmacokinetics (PK)

Provided by TargetMol

PK studies involve the use of in vivo animal models, in vitro experiments, and virtualsimulations to reveal the dynamic behavior of drugs within the body, These studies aim to obtain fundamentalpharmacokinetic parameters of the drug and to elucidate the processes and characteristics of its absorptiondistribution.metabolism,and excretion(ADME) Pharmacokinetics plays a critical role in evaluating new drug development, it provides valuable reference informationfor predictingthe bioavailability and biological activity of drugs.

The process and characteristics of ADME

Distribution (D) refers to the process by which a drug is transported from the blood to various tissues and organs. Drug distribution in the body is often selective and generally uneven. After a period of time, drug concentrations in the blood and tissues reach a relative equilibrium. At this point, plasma drug concentration can indirectly reflect the drug levels in target and non-target organs, allowing prediction of the relationship between plasma concentration and drug efficacy or toxicity.

Metabolism (M) occurs simultaneously with absorption and distribution. Under the action of drug-metabolizing enzymes, drugs undergo chemical modifications. Some water-soluble drugs are excreted unchanged via the kidneys, whereas most lipophilic drugs are metabolized into more polar or water-soluble metabolites for renal excretion.

Excretion (E) refers to the elimination of drugs or their metabolites from the body through excretory or secretory organs. The kidneys are the primary excretory organ, while biliary excretion is another major elimination pathway.

TargetMol provides comprehensive pharmacokinetic research services for scientists. We study the PK characteristics of compounds in mice, rats, and Beagle dogs, investigate their absorption, distribution, and elimination mechanisms using specific animal models, and evaluate the rate and extent of blood–brain barrier penetration. These studies provide key PK parameters in preclinical species, supporting structure–activity and structure–PK relationship analyses for drug development.