Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CX 717 is a positive allosteric modulator of AMPA receptor which has an antidepressant-like effect. CX 717 can be used for the research of adult attention deficit hyperactivity disorder (ADHD) [1] [2].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 39.00 | |
10 mg | In stock | $ 64.00 | |
25 mg | In stock | $ 128.00 | |
50 mg | In stock | $ 198.00 | |
100 mg | In stock | $ 328.00 | |
200 mg | In stock | $ 489.00 |
Description | CX 717 is a positive allosteric modulator of AMPA receptor which has an antidepressant-like effect. CX 717 can be used for the research of adult attention deficit hyperactivity disorder (ADHD) [1] [2]. |
In vivo | CX 717 (CX717; 20 mg/kg) demonstrates a quick (30 min) yet brief (up to 24 h) antidepressant-like response in the forced swim test. Additionally, it induces a rapid increase in brain-derived neurotrophic factor (BDNF) within 1 hour and maintains elevated levels of p11 for up to 6 hours [2]. When infused intra-cortically at 85 mM, CX 717 escalates the efflux of noradrenaline, dopamine, and serotonin, without affecting glutamate levels [2]. The study utilized male Sprague-Dawley rats weighing 280-350 g [2], administered a dosage of 20 mg/kg (at 1 mL/kg) via intraperitoneal injection. The outcomes showed that CX 717, at a dosage of 20 mg/kg delivered intraperitoneally, provoked antidepressant-like effects without modifying the extracellular concentrations of noradrenaline (NA), dopamine (DA), serotonin (5-HT), and glutamate in the medial prefrontal cortex (mPFC). |
Molecular Weight | 233.23 |
Formula | C11H11N3O3 |
CAS No. | 867276-98-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (193 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. More
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CX717 867276-98-0 Neuroscience GluR CX-717 CX 717 inhibitor inhibit