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GDF-15 Protein, Mouse, Recombinant (hFc)
(Synonyms: RG-1, PTGF-β, PTGFBPTGF-β, PTGFBPTGF-beta, PTGF-beta, PTGFB, Placental TGF-β, Placental TGF-beta, PLAB, PDF, NAG-1, MIC-1, MIC1, GDF-15, GDF15) Copy Product InfoSynonyms: RG-1, PTGF-β, PTGFBPTGF-β, PTGFBPTGF-beta, PTGF-beta, PTGFB, Placental TGF-β, Placental TGF-beta, PLAB, PDF, NAG-1, MIC-1, MIC1, GDF-15, GDF15
Catalog No. TMPK-01244 Copy Product Info
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 37.9 kDa and the accession number is Q9Z0J7.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $58 | - | In Stock | |
| 10 μg | $92 | - | In Stock | |
| 20 μg | $148 | - | In Stock | |
| 50 μg | $289 | - | In Stock | |
| 100 μg | $487 | - | In Stock | |
| 200 μg | $883 | 7-10 days | 7-10 days | |
| 500 μg | $1,950 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Appearance:Lyophilized powder
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Immobilized Mouse GFRAL, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Mouse GDF15, hFc Tag with the EC50 of 3.0ng/ml determined by ELISA. |
| Description | Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 37.9 kDa and the accession number is Q9Z0J7. |
| Species | Mouse |
| Expression System | HEK293 Cells |
| Tag | N-hFc |
| Accession Number | Q9Z0J7 |
| Construction | Ser189-Ala303 |
| Protein Purity | > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | RG-1, PTGF-β, PTGFBPTGF-β, PTGFBPTGF-beta, PTGF-beta, PTGFB, Placental TGF-β, Placental TGF-beta, PLAB, PDF, NAG-1, MIC-1, MIC1, GDF-15, GDF15 |
| Research Background | Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. |
| Molecular Weight | 37.9 kDa (predicted). Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result. |
| Storage | Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: GDF-15 Protein, Mouse, Recombinant (hFc) chemical structure | GDF-15 Protein, Mouse, Recombinant (hFc) molecular weight
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