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Xanomeline oxalate

Name: Xanomeline oxalate
Brand: TargetMol
SKU: T13353
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13353Cas No. 141064-23-5

Alias LY246708 oxalate

Xanomeline oxalate (LY246708 oxalate), a potent and selective muscarinic receptor agonist (SMRA), effectively stimulates in vivo phosphoinositide hydrolysis. It is a valuable compound for Alzheimer's disease research.

Xanomeline oxalate

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Purity: 99.1%

Catalog No. T13353Alias LY246708 oxalateCas No. 141064-23-5

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$32	In Stock	In Stock
10 mg	$53	In Stock	In Stock
25 mg	$107	In Stock	In Stock
50 mg	$171	In Stock	In Stock
100 mg	$272	In Stock	In Stock
200 mg	$392	-	In Stock
1 mL x 10 mM (in DMSO)	$35	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.1%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Xanomeline oxalate (LY246708 oxalate), a potent and selective muscarinic receptor agonist (SMRA), effectively stimulates in vivo phosphoinositide hydrolysis. It is a valuable compound for Alzheimer's disease research.
In vitro	Xanomeline stimulates phosphoinositide (PI) hydrolysis in A9 L m1 cells and inhibits [3H]-PZ and [3H]-OXO-M binding to rat brain, with Kis of 7 and 3 nM, respectively[1].
In vivo	Xanomeline robustly stimulates in vivo PI hydrolysis, an effect blocked by muscarinic antagonists, indicating mediation by muscarinic receptors. In mice, the ED100 for Xanomeline-induced stimulation of [3H]-IP accumulation in the hippocampus is 54 μmole/kg, while in rats, it is 8.1 μmole/kg in the hippocampus[1].
Synonyms	LY246708 oxalate

Chemical Properties

Molecular Weight	371.45
Formula	C₁₆H₂₅N₃O₅S
Cas No.	141064-23-5
Smiles	OC(=O)C(O)=O.CCCCCCOc1nsnc1C1=CCCN(C)C1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (121.15 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.38 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6922 mL	13.4608 mL	26.9215 mL	134.6076 mL
5 mM	0.5384 mL	2.6922 mL	5.3843 mL	26.9215 mL
10 mM	0.2692 mL	1.3461 mL	2.6922 mL	13.4608 mL
20 mM	0.1346 mL	0.6730 mL	1.3461 mL	6.7304 mL
50 mM	0.0538 mL	0.2692 mL	0.5384 mL	2.6922 mL
100 mM	0.0269 mL	0.1346 mL	0.2692 mL	1.3461 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc