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Xanomeline oxalate

🥰Excellent
Catalog No. T13353Cas No. 141064-23-5
Alias LY246708 oxalate

Xanomeline oxalate (LY246708 oxalate), a potent and selective muscarinic receptor agonist (SMRA), effectively stimulates in vivo phosphoinositide hydrolysis. It is a valuable compound for Alzheimer's disease research.

Xanomeline oxalate
Other Forms of Xanomeline oxalate:

Xanomeline oxalate

🥰Excellent
Purity: 99.1%
Catalog No. T13353Alias LY246708 oxalateCas No. 141064-23-5
Xanomeline oxalate (LY246708 oxalate), a potent and selective muscarinic receptor agonist (SMRA), effectively stimulates in vivo phosphoinositide hydrolysis. It is a valuable compound for Alzheimer's disease research.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$32In StockIn Stock
10 mg$53In StockIn Stock
25 mg$107In StockIn Stock
50 mg$171In StockIn Stock
100 mg$272In StockIn Stock
200 mg$392-In Stock
1 mL x 10 mM (in DMSO)$35In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.1%
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Product Introduction

Bioactivity
Description
Xanomeline oxalate (LY246708 oxalate), a potent and selective muscarinic receptor agonist (SMRA), effectively stimulates in vivo phosphoinositide hydrolysis. It is a valuable compound for Alzheimer's disease research.
In vitro
Xanomeline stimulates phosphoinositide (PI) hydrolysis in A9 L m1 cells and inhibits [3H]-PZ and [3H]-OXO-M binding to rat brain, with Kis of 7 and 3 nM, respectively[1].
In vivo
Xanomeline robustly stimulates in vivo PI hydrolysis, an effect blocked by muscarinic antagonists, indicating mediation by muscarinic receptors. In mice, the ED100 for Xanomeline-induced stimulation of [3H]-IP accumulation in the hippocampus is 54 μmole/kg, while in rats, it is 8.1 μmole/kg in the hippocampus[1].
SynonymsLY246708 oxalate
Chemical Properties
Molecular Weight371.45
FormulaC16H25N3O5S
Cas No.141064-23-5
SmilesOC(=O)C(O)=O.CCCCCCOc1nsnc1C1=CCCN(C)C1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 45 mg/mL (121.15 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.38 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6922 mL13.4608 mL26.9215 mL134.6076 mL
5 mM0.5384 mL2.6922 mL5.3843 mL26.9215 mL
10 mM0.2692 mL1.3461 mL2.6922 mL13.4608 mL
20 mM0.1346 mL0.6730 mL1.3461 mL6.7304 mL
50 mM0.0538 mL0.2692 mL0.5384 mL2.6922 mL
100 mM0.0269 mL0.1346 mL0.2692 mL1.3461 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Keywords

Xanomeline Oxalatemuscarinic receptorLY-246708 OxalateLY246708 OxalateLY 246708 Oxalate
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