Galectin-3-IN-7

Name: Galectin-3-IN-7
Brand: TargetMol
SKU: T214503
Rating: 4.5 (1 reviews)

Catalog No. T214503 Copy Product Info

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Galectin-3-IN-7 is a selective Galectin-3 inhibitor with a Kd value of 5.7 nM, demonstrating a selectivity over Gal-1 that is 390 times greater. It downregulates pro-fibrotic signaling pathways, including ACTA2, COL1A2, and FN1, in TGFβ-stimulated LX2 hepatic stellate cells. Galectin-3-IN-7 is useful in fibrosis research.

Galectin-3-IN-7

Copy Product Info

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Catalog No. T214503

Galectin-3-IN-7

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Galectin-3-IN-7 is a selective Galectin-3 inhibitor with a Kd value of 5.7 nM, demonstrating a selectivity over Gal-1 that is 390 times greater. It downregulates pro-fibrotic signaling pathways, including ACTA2, COL1A2, and FN1, in TGFβ-stimulated LX2 hepatic stellate cells. Galectin-3-IN-7 is useful in fibrosis research.
Targets&IC50	Galectin 3:5.7 nM (Kd)
In vitro	Galectin-3-IN-7 (Compound 11) exhibits moderate plasma protein binding in human, mouse, and rat plasma at 45%, 43%, and 90% respectively. The compound has a CC50 greater than 300 μM when tested for 24 hours with concentrations ranging from 3.7 to 300 μM on HEK293, HepG2, THP-1, Jurkat E6.1, and LX2 cells. It does not significantly inhibit LPS-induced TNFα secretion in THP-1 macrophage-like cells. However, in a dose-dependent manner, Galectin-3-IN-7 downregulates the mRNA expression of ACTA2, COL1A2, and FN1 in TGFβ1-stimulated LX2 cells.

Chemical Properties

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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