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NT219

Catalog No. T62105 CAS 1198078-60-2

Synonyms: NT-219

NT219 is a dual inhibitor of insulin receptor substrate 1/2 (IRS1/2) and STAT3, enhances the aggregation of misfolded prion protein NT219 affects the levels of certain molecular chaperones and inhibits STAT3 phosphorylation NT219 is useful for the study of cancer and neurodegenerative diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

NT219, CAS 1198078-60-2

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,400.00
50 mg	6-8 weeks	$ 1,820.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

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Purity: 98.06%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	NT-219
Molecular Weight	412.26
Formula	C16H14BrNO5S
CAS No.	1198078-60-2

Storage

keep away from direct sunlight,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (194.17 mM)

References and Literature

1. Alberto Bessudo, et al. A phase 1/2 study with open-label, dose escalation phase followed by single-arm expansion at the maximum tolerated dose to assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of NT219 injection alone and in combination with cetuximab in adults with advanced solid tumors and head and neck cancer.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NT219 1198078-60-2 JAK/STAT signaling Stem Cells STAT NT-219 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.