Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

DY-46-2

Name: DY-46-2
Brand: TargetMol
SKU: T62643
Rating: 4.5 (1 reviews)

Copy Product Info

😃Good

Catalog No. T62643Cas No. 1105110-83-5

DY-46-2 is a selective non-nucleoside DNA methyltransferase 3A (DNMT3A) inhibitor (IC50: 0.39 ± 0.23 μM) with anticancer activity for the study of cancer and tumors.

DY-46-2

Copy Product Info

😃Good

Purity: 99.12%

Catalog No. T62643Cas No. 1105110-83-5

DY-46-2 is a selective non-nucleoside DNA methyltransferase 3A (DNMT3A) inhibitor (IC50: 0.39 ± 0.23 μM) with anticancer activity for the study of cancer and tumors.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	Inquiry	8-10 weeks	8-10 weeks
25 mg	Inquiry	8-10 weeks	8-10 weeks
50 mg	Inquiry	8-10 weeks	8-10 weeks
100 mg	Inquiry	8-10 weeks	8-10 weeks

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.12%

Appearance:Solid

Color:White

Resource Download

COA

Product Introduction

Bioactivity

Description	DY-46-2 is a selective non-nucleoside DNA methyltransferase 3A (DNMT3A) inhibitor (IC50: 0.39 ± 0.23 μM) with anticancer activity for the study of cancer and tumors.
Targets&IC50	THP-1 cells:0.7 μM, DNMT3A:0.39 μM, DNMT3B:105 μM, G9a:>500 μM, DNMT1:13.0 μM, HCT116 cells:0.3 μM
In vitro	DY-46-2 (0.1-100 μM, treated for 24, 48 and 72 h) showed inhibitory activity against DNMT3A with an IC50 value of 0.39 μM, and this inhibition increased linearly with increasing DNA concentration. DY-46-2 also showed inhibitory activity against DNMT1, DNMT3B and G9a with IC50 values of 13.0 μM, 105 μM and >500 μM, respectively. In a variety of cancer cell lines, DY-46-2 showed different cell viability inhibitory effects with the following IC50 values: THP-1 cells: 0.7 μM; HCT116 cells: 0.3 μM; U937 cells: 0.7 μM; K562 cells: 0.5 μM; A549 cells: 2.1 μM; DU145 cells: 1.7 μM; PBMC cells: 91 μM. DY-46-2 significantly inhibited the proliferation of cancer cells and showed low cytotoxicity in peripheral blood mononuclear cells (PBMCs). [1]

Chemical Properties

Molecular Weight	446.48
Formula	C₁₉H₂₂N₆O₅S
Cas No.	1105110-83-5
Smiles	O=C(NC1=CN=C(C=C1)S(=O)(=O)N)C2=C(OC=3N=CN(C(=O)C32)CCN4CCCC4)C

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (89.59 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2397 mL	11.1987 mL	22.3974 mL	111.9871 mL
5 mM	0.4479 mL	2.2397 mL	4.4795 mL	22.3974 mL
10 mM	0.2240 mL	1.1199 mL	2.2397 mL	11.1987 mL
20 mM	0.1120 mL	0.5599 mL	1.1199 mL	5.5994 mL
50 mM	0.0448 mL	0.2240 mL	0.4479 mL	2.2397 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc