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EZH2-IN-15

Name: EZH2-IN-15
Brand: TargetMol
SKU: T67883
Price: 139 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T67883Cas No. 2098545-98-1

Alias SHR2554

EZH2-IN-15 (SHR2554) is a specific inhibitor of the zeste 2 histone modification enhancer (EZH2).EZH2 is aberrantly overexpressed in many human cancers and controls adaptive responses by regulating Treg activity. EZH2 expression in tumors has also been shown to control innate immunity.

EZH2-IN-15

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Purity: 99.88%

Catalog No. T67883Alias SHR2554Cas No. 2098545-98-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$139	In Stock	In Stock
5 mg	$286	In Stock	In Stock
10 mg	$377	In Stock	In Stock
25 mg	$643	In Stock	In Stock
50 mg	$977	In Stock	In Stock
100 mg	$1,460	-	In Stock
1 mL x 10 mM (in DMSO)	$346	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.88%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	EZH2-IN-15 (SHR2554) is a specific inhibitor of the zeste 2 histone modification enhancer (EZH2).EZH2 is aberrantly overexpressed in many human cancers and controls adaptive responses by regulating Treg activity. EZH2 expression in tumors has also been shown to control innate immunity.
In vitro	As measured by CellTiter-Glo Luminescent Cell Viability Assay Method, EZH2-IN-15 IC50 = 0.87 nM for EZH2 wild type and IC50 = 1.63 nM for H3K27me3 in Pfeiffer cells.[3]
Synonyms	SHR2554

Chemical Properties

Molecular Weight	548.72
Formula	C₃₂H₄₄N₄O₄
Cas No.	2098545-98-1
Smiles	CCN(C1CCOCC1)c1cc2oc(CN3CCCCC3)cc2c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1CC

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (91.12 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8224 mL	9.1121 mL	18.2242 mL	91.1212 mL
5 mM	0.3645 mL	1.8224 mL	3.6448 mL	18.2242 mL
10 mM	0.1822 mL	0.9112 mL	1.8224 mL	9.1121 mL
20 mM	0.0911 mL	0.4556 mL	0.9112 mL	4.5561 mL
50 mM	0.0364 mL	0.1822 mL	0.3645 mL	1.8224 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc