Shopping Cart

Your shopping cart is currently empty

FG 7142

Name: FG 7142
Brand: TargetMol
SKU: T11277
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T11277Cas No. 78538-74-6

Alias ZK 39106, LSU-65

FG 7142 (LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex. FG 7142 , a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM).

FG 7142

😃Good

Purity: 98.75%

Catalog No. T11277Alias ZK 39106, LSU-65Cas No. 78538-74-6

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$29	In Stock	In Stock
5 mg	$58	In Stock	In Stock
10 mg	$98	In Stock	In Stock
25 mg	$160	In Stock	In Stock
50 mg	$237	In Stock	In Stock
100 mg	$353	In Stock	In Stock
200 mg	$490	-	In Stock
1 mL x 10 mM (in DMSO)	$35	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.75%

Appearance:Solid

Color:White

Resource Download

COA HPLC LCMS HNMR

Product Introduction

Bioactivity

Description	FG 7142 (LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex. FG 7142 , a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM).
Targets&IC50	GABAA receptor:ki： 91 nM
In vitro	FG-7142 has a high efficacy in modulating GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50 = 137 nM) as compared to the other α subunits.FG-7142 has affinity for those expressing the α subunit, the Ki values are 91 nM; 330 nM; 492 nM and 2.150 μM for α1, α2,α3 and α5 subunits, respectively.
In vivo	FG-7142, administered via intraperitoneal injection at doses of 15 mg/kg, enhances tyrosine hydroxylase activity and dopamine turnover specifically in the medial prefrontal cortex and ventral tegmentum, without impacting mesolimbic or nigrostriatal regions. At doses between 15-30 mg/kg, it stimulates mesolimbocortical dopaminergic projections, resulting in elevated dopamine levels in the prefrontal cortex and nucleus accumbens in rats.
Synonyms	ZK 39106, LSU-65

Chemical Properties

Molecular Weight	225.25
Formula	C₁₃H₁₁N₃O
Cas No.	78538-74-6
Smiles	CNC(=O)c1cc2c(cn1)[nH]c1ccccc21
Relative Density.	1.328 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (133.19 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.88 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4395 mL	22.1976 mL	44.3951 mL	221.9756 mL
5 mM	0.8879 mL	4.4395 mL	8.8790 mL	44.3951 mL
10 mM	0.4440 mL	2.2198 mL	4.4395 mL	22.1976 mL
20 mM	0.2220 mL	1.1099 mL	2.2198 mL	11.0988 mL
50 mM	0.0888 mL	0.4440 mL	0.8879 mL	4.4395 mL
100 mM	0.0444 mL	0.2220 mL	0.4440 mL	2.2198 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc