Shopping Cart

Your shopping cart is currently empty

hCAII-IN-9

Name: hCAII-IN-9
Brand: TargetMol
SKU: T73177
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T73177Cas No. 2878477-18-8

hCAII-IN-9 is a potent carbonic anhydrase inhibitor with IC50 values of 1.18 μM for hCA II, 0.17 μM for hCA IX, and 2.99 μM for hCA XII. It is not blood-brain barrier permeable.

hCAII-IN-9

Copy Product Info

😃Good

Purity: 99.87%

Catalog No. T73177Cas No. 2878477-18-8

hCAII-IN-9 is a potent carbonic anhydrase inhibitor with IC50 values of 1.18 μM for hCA II, 0.17 μM for hCA IX, and 2.99 μM for hCA XII. It is not blood-brain barrier permeable.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$62	In Stock	In Stock
10 mg	$90	In Stock	In Stock
25 mg	$153	In Stock	In Stock
50 mg	$232	In Stock	In Stock
100 mg	$333	In Stock	In Stock
200 mg	$488	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.87%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	hCAII-IN-9 is a potent carbonic anhydrase inhibitor with IC50 values of 1.18 μM for hCA II, 0.17 μM for hCA IX, and 2.99 μM for hCA XII. It is not blood-brain barrier permeable.
Targets&IC50	CA XII (human):2.99 μM, CA IX (human):0.17 μM, CA II (human):1.18 μM
In vitro	HCAII-IN-9 (Compound 11) (100 μM; 24-48 h) inhibits BHK-21 and HEK-293 cells with cell viability of 48% and 72%, respectively.[1]

Chemical Properties

Molecular Weight	417.89
Formula	C₁₅H₁₆ClN₃O₅S₂
Cas No.	2878477-18-8
Smiles	S(N)(=O)(=O)C1=C(NC(=O)C2=CC(C)=CC(C)=C2)C=C(Cl)C(S(N)(=O)=O)=C1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (131.61 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3930 mL	11.9649 mL	23.9297 mL	119.6487 mL
5 mM	0.4786 mL	2.3930 mL	4.7859 mL	23.9297 mL
10 mM	0.2393 mL	1.1965 mL	2.3930 mL	11.9649 mL
20 mM	0.1196 mL	0.5982 mL	1.1965 mL	5.9824 mL
50 mM	0.0479 mL	0.2393 mL	0.4786 mL	2.3930 mL
100 mM	0.0239 mL	0.1196 mL	0.2393 mL	1.1965 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc