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hCAII-IN-9

Name: hCAII-IN-9
Brand: TargetMol
SKU: T73177
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T73177Cas No. 2878477-18-8

hCAII-IN-9 is a potent carbonic anhydrase inhibitor with IC50 values of 1.18 μM for hCA II, 0.17 μM for hCA IX, and 2.99 μM for hCA XII. It is not blood-brain barrier permeable.

hCAII-IN-9

🥰Excellent

Purity: 98.63%

Catalog No. T73177Cas No. 2878477-18-8

hCAII-IN-9 is a potent carbonic anhydrase inhibitor with IC50 values of 1.18 μM for hCA II, 0.17 μM for hCA IX, and 2.99 μM for hCA XII. It is not blood-brain barrier permeable.

Pack Size	Price	Availability
1 mg	$30	In Stock
5 mg	$62	In Stock
10 mg	$90	In Stock
25 mg	$153	In Stock
50 mg	$232	In Stock
100 mg	$333	In Stock
200 mg	$488	In Stock

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Batch Information

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Purity:98.63%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	hCAII-IN-9 is a potent carbonic anhydrase inhibitor with IC50 values of 1.18 μM for hCA II, 0.17 μM for hCA IX, and 2.99 μM for hCA XII. It is not blood-brain barrier permeable.
Targets&IC50	CA IX (human):0.17 μM, CA XII (human):2.99 μM, CA II (human):1.18 μM
In vitro	HCAII-IN-9 (Compound 11) (100 μM; 24-48 h) inhibits BHK-21 and HEK-293 cells with cell viability of 48% and 72%, respectively.[1]

Chemical Properties

Molecular Weight	417.89
Formula	C₁₅H₁₆ClN₃O₅S₂
Cas No.	2878477-18-8
Smiles	S(N)(=O)(=O)C1=C(NC(=O)C2=CC(C)=CC(C)=C2)C=C(Cl)C(S(N)(=O)=O)=C1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (131.61 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3930 mL	11.9649 mL	23.9297 mL	119.6487 mL
5 mM	0.4786 mL	2.3930 mL	4.7859 mL	23.9297 mL
10 mM	0.2393 mL	1.1965 mL	2.3930 mL	11.9649 mL
20 mM	0.1196 mL	0.5982 mL	1.1965 mL	5.9824 mL
50 mM	0.0479 mL	0.2393 mL	0.4786 mL	2.3930 mL
100 mM	0.0239 mL	0.1196 mL	0.2393 mL	1.1965 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc