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Anti-CXCL1 Antibody (7E516)

😃Good
Catalog No. TMAY-01272
Alias SCYB1, P450c21B, NAP-3, MGSA-a, MGSA, GROa, GRO1, CYP21B, CYP21, CPS1, chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, α), chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha), CAH1, CA21H

Anti-CXCL1 Antibody (7E516) is a Mouse antibody targeting CXCL1. Anti-CXCL1 Antibody (7E516) can be used in ELISA.

Anti-CXCL1 Antibody (7E516)

Anti-CXCL1 Antibody (7E516)

😃Good
Catalog No. TMAY-01272Alias SCYB1, P450c21B, NAP-3, MGSA-a, MGSA, GROa, GRO1, CYP21B, CYP21, CPS1, chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, α), chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha), CAH1, CA21H
Anti-CXCL1 Antibody (7E516) is a Mouse antibody targeting CXCL1. Anti-CXCL1 Antibody (7E516) can be used in ELISA.
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100 μL$199 7-10 days
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Product Introduction

Bioactivity
Description
Anti-CXCL1 Antibody (7E516) is a Mouse antibody targeting CXCL1. Anti-CXCL1 Antibody (7E516) can be used in ELISA.
AliasSCYB1, P450c21B, NAP-3, MGSA-a, MGSA, GROa, GRO1, CYP21B, CYP21, CPS1, chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, α), chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha), CAH1, CA21H
Ig Type
Monoclonal Mouse IgG2b
Clone
7E516
Reactivity
Human
Application
ELISA
Recommended Dose
ELISA: 1:1000-1:2000
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CXCL1 (rh CXCL1; TMPY-02868; P09341-1; Ala35-Asn107). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundThe Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-a). CXCL1 already known to be important in osteoarthritis (OA), as a novel target gene of transcription factor AP-2? in chondrocytes and support the important role of AP-2? in cartilage. CXCL1 is a potent neutrophil chemoattractant with recognized roles in angiogenesis and inflammation. CXCL1 is a novel immediate PTH/PTHrP-responsive gene. CXCL1 may act as a chemoattractant for osteoclast precursors. CXCL1 may also have important pro-nociceptive effects via its direct actions on sensory neurons, and may induce long-term changes that involve protein synthesis. CXCL1 plays a critical nonredundant role in the development of experimental Lyme arthritis and carditis via CXCR2-mediated recruitment of neutrophils into the site of infection. CXCL1 functions through CXCR2 to transactivate the EGFR by proteolytic cleavage of HB-EGF, leading to activation of MAPK signalling and increased proliferation of epithelial ovarian cancer (EOC) cells. It might limit tumor growth by reinforcing senescence early in tumorigenesis. Thus, CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human CXCL1 Protein (TMPY-02868)
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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