PF-03715455

Name: PF-03715455
Brand: TargetMol
SKU: T16477
Rating: 4.5 (1 reviews)

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Catalog No. T16477Cas No. 1056164-52-3

PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM). PF-03715455 is an effective inhibitor of inhaled p38 MAPK. PF-03715455 displays some selectivity for p38α over p38β (respective IC50: 0.88 and 23 nM). PF-03715455 has the potential for the treatment of COPD.

PF-03715455

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Catalog No. T16477Cas No. 1056164-52-3

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$2,720	3-6 months	3-6 months
50 mg	$3,580	3-6 months	3-6 months
100 mg	$4,900	3-6 months	3-6 months

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM). PF-03715455 is an effective inhibitor of inhaled p38 MAPK. PF-03715455 displays some selectivity for p38α over p38β (respective IC50: 0.88 and 23 nM). PF-03715455 has the potential for the treatment of COPD.
Targets&IC50	p38β:23 nM, p38α:0.88 nM
In vitro	PF-03715455 is a moderate inhibitor of CYP1A2, CYP2C19, and CYP2D6, and a potent inhibitor of CYP2C9 and CYP3A4[2].
In vivo	PF-03715455 treatment displays that the Vss is 0.19 L/kg and T1/2 is 1 hour [2].

Chemical Properties

Molecular Weight	700.27
Formula	C₃₅H₃₄ClN₇O₃S₂
Cas No.	1056164-52-3
Smiles	S(C1=CN2C(=NN=C2C=C1)C3=C(SCCO)C=CC=C3)C4=C(CNC(NC=5N(N=C(C(C)(C)C)C5)C6=CC(Cl)=C(O)C=C6)=O)C=CC=C4
Relative Density.	1.39 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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