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ML 154

Name: ML 154
Brand: TargetMol
SKU: T22994
Price: 53 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22994Cas No. 1345964-89-7

ML 154 is a potent neuropeptide S receptor (NPSR) antagonist.

ML 154

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Purity: 99.53%

Catalog No. T22994Cas No. 1345964-89-7

ML 154 is a potent neuropeptide S receptor (NPSR) antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$53	In Stock	In Stock
2 mg	$73	In Stock	In Stock
5 mg	$113	In Stock	In Stock
10 mg	$159	In Stock	In Stock
25 mg	$293	In Stock	In Stock
50 mg	$419	In Stock	In Stock
100 mg	$580	In Stock	In Stock
200 mg	$783	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.53%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

ML 154 AI Summary

ML 154 exhibits a diverse range of bioactivities. It demonstrates potent antagonistic effects on the Neuropeptide S receptor, affecting calcium signal transduction with a potency of 0.9381 nM and cAMP signal transduction at 44.5 nM. It inhibits Nrf2 with a potency of 29092.9 nM and TGF-β with potencies of 19952.6 nM and 15848.9 nM. Additionally, it shows high potency in radioligand displacement assays at 1.0 nM and impacts PINK1 expression, PTHR inhibition, and antiviral activity against foot-and-mouth disease virus with potencies from 125892.5 nM to 44668.4 nM. Despite these activities, it shows relatively weak inhibition against Trypanosoma brucei RNA editing ligase 1 (IC50 > 96559.0 nM). ML 154 also modulates beta-arrestin recruitment in various GPCR assays, inhibiting targets including GPR35, AGTR1, FPR2, ADRB2, APLNR, CX3CR1, S1PR1, FFAR4, ADGRF1, C5AR1, and GLP1R with varying degrees of inhibition. It affects the thermal stability of several protein domains, suggesting complex interactions that can both stabilize and destabilize different regions. Furthermore, it exhibits stability in mouse liver microsomes and high brain uptake with a half-life of 8.8 hours. These diverse bioactivities warrant further investigation to elucidate its potential therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

ML 154 is a potent neuropeptide S receptor (NPSR) antagonist.

Chemical Properties

Molecular Weight	545.47
Formula	C₂₉H₂₆BrN₂PS
Cas No.	1345964-89-7
Smiles	CC1=C(P(C2=CC=CC=C2)(C3=CC=CC=C3)=S)[N+]4=CC=CC=C4N1C/C([H])=C([H])/C5=CC=CC=C5.[Br-]
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (100.83 mM), Sonication is recommended.

Ethanol: < 27.27 mg/mL, Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8333 mL	9.1664 mL	18.3328 mL	91.6641 mL
5 mM	0.3667 mL	1.8333 mL	3.6666 mL	18.3328 mL
10 mM	0.1833 mL	0.9166 mL	1.8333 mL	9.1664 mL
20 mM	0.0917 mL	0.4583 mL	0.9166 mL	4.5832 mL
50 mM	0.0367 mL	0.1833 mL	0.3667 mL	1.8333 mL
100 mM	0.0183 mL	0.0917 mL	0.1833 mL	0.9166 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc