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CJJ300

Catalog No. T62483 CAS 1807631-83-9

CJJ300 is a transforming growth factor-β (TGF-β) inhibitor (IC50 : 5.3 μM).CJJ300 inhibits TGF-β signaling by disrupting the formation of the TGF-β-TβR-I-TβR-II signaling complex.CJJ300 inhibits cell migration.

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CJJ300, CAS 1807631-83-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 44.00
5 mg	In stock	$ 105.00
10 mg	In stock	$ 172.00
25 mg	In stock	$ 363.00
50 mg	In stock	$ 578.00
100 mg	In stock	$ 828.00
500 mg	In stock	$ 1,690.00

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Purity: 99.41%

Biological Description

Chemical Properties

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Description	CJJ300 is a transforming growth factor-β (TGF-β) inhibitor (IC50 : 5.3 μM).CJJ300 inhibits TGF-β signaling by disrupting the formation of the TGF-β-TβR-I-TβR-II signaling complex.CJJ300 inhibits cell migration.
Targets&IC50	TGF β1:5.3 µM
In vitro	CJJ300 (20, 40, and 80 µM, 2 h; Human A549 lung epithelial cells) inhibits the phosphorylation of intracellular mediators in the downstream TGF-β signaling pathways, significantly attenuated the increasement of P-Smad2/Smad3, P-Erk1/2, and P-Akt induced by TGF-β. Downregulated the expression of EMT-associated proteins, including fibronectin, α-SMA, and MMP-2 in a dose-dependent manner without cytotoxicity. CJJ300 disturbs protein-protein interactions and prevents TGF-β receptor dimerization (IC50 = 23.6 ± 5.8 µM). CJJ300 suppresses TGF-β induced cell migration.[1]

Molecular Weight	435.6
Formula	C30H33N3
CAS No.	1807631-83-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Wu H, et al. The development of a novel transforming growth factor-β (TGF-β) inhibitor that disrupts ligand-receptor interactions. Eur J Med Chem. 2020;189:112042.

Related compound libraries

This product is contained In the following compound libraries：

TGF-beta/Smad Compound Library Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CJJ300 1807631-83-9 Stem Cells TGF-beta/Smad inhibitor inhibit

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