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CJJ300

Name: CJJ300
Brand: TargetMol
SKU: T62483
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T62483Cas No. 1807631-83-9

CJJ300 is a transforming growth factor-β (TGF-β) inhibitor with an IC50 of 5.3 μM, disrupting the TGF-β-TβR-I-TβR-II signaling complex and inhibiting cell migration.

CJJ300

🥰Excellent

Purity: 99.51%

Catalog No. T62483Cas No. 1807631-83-9

CJJ300 is a transforming growth factor-β (TGF-β) inhibitor with an IC50 of 5.3 μM, disrupting the TGF-β-TβR-I-TβR-II signaling complex and inhibiting cell migration.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$47	In Stock	In Stock
10 mg	$83	In Stock	In Stock
25 mg	$167	In Stock	In Stock
50 mg	$273	In Stock	In Stock
100 mg	$413	In Stock	In Stock
200 mg	$582	-	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.51%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	CJJ300 is a transforming growth factor-β (TGF-β) inhibitor with an IC50 of 5.3 μM, disrupting the TGF-β-TβR-I-TβR-II signaling complex and inhibiting cell migration.
Targets&IC50	TGFβ1:5.3 µM
In vitro	CJJ300 (20, 40, and 80 µM, 2 h; Human A549 lung epithelial cells) inhibits the phosphorylation of intracellular mediators in the downstream TGF-β signaling pathways, significantly attenuated the increasement of P-Smad2/Smad3, P-Erk1/2, and P-Akt induced by TGF-β. Downregulated the expression of EMT-associated proteins, including fibronectin, α-SMA, and MMP-2 in a dose-dependent manner without cytotoxicity. CJJ300 disturbs protein-protein interactions and prevents TGF-β receptor dimerization (IC50 = 23.6 ± 5.8 µM). CJJ300 suppresses TGF-β induced cell migration.[1]

Chemical Properties

Molecular Weight	435.6
Formula	C₃₀H₃₃N₃
Cas No.	1807631-83-9
Smiles	C(NC1=CC=CC=C1)C2=C(C)C(CNC3=CC=CC=C3)=C(C)C(CNC4=CC=CC=C4)=C2C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (229.57 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (7.58 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2957 mL	11.4784 mL	22.9568 mL	114.7842 mL
5 mM	0.4591 mL	2.2957 mL	4.5914 mL	22.9568 mL
10 mM	0.2296 mL	1.1478 mL	2.2957 mL	11.4784 mL
20 mM	0.1148 mL	0.5739 mL	1.1478 mL	5.7392 mL
50 mM	0.0459 mL	0.2296 mL	0.4591 mL	2.2957 mL
100 mM	0.0230 mL	0.1148 mL	0.2296 mL	1.1478 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc