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Anti-SLAMF7 Antibody (5K697) (Synonyms: SLAM7, SLAM family member 7, CS1, CRACC, CD319, 19A)

Name: Anti-SLAMF7 Antibody (5K697)
Brand: TargetMol
SKU: TMAY-03171
Rating: 4.5 (1 reviews)

Catalog No. TMAY-03171 Copy Product Info

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Anti-SLAMF7 Antibody (5K697) is a Rabbit antibody targeting SLAMF7. Anti-SLAMF7 Antibody (5K697) can be used in ELISA.

Anti-SLAMF7 Antibody (5K697)

Copy Product Info

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Catalog No. TMAY-03171

Synonyms SLAM7, SLAM family member 7, CS1, CRACC, CD319, 19A

Anti-SLAMF7 Antibody (5K697) is a Rabbit antibody targeting SLAMF7. Anti-SLAMF7 Antibody (5K697) can be used in ELISA.

Anti-SLAMF7 Antibody
(5K697)

Pack Size	Price	USA Stock	Global Stock	Quantity
100 μL	$268	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Instruction Manual of Detection Antibody

Product Introduction

Bioactivity

Description	Anti-SLAMF7 Antibody (5K697) is a Rabbit antibody targeting SLAMF7. Anti-SLAMF7 Antibody (5K697) can be used in ELISA.
Synonyms	SLAM7, SLAM family member 7, CS1, CRACC, CD319, 19A
Ig Type	Rabbit IgG
Clone	5K697
Reactivity	Mouse
Specificity	Mouse SLAMF7/CRACC/CS1 Has cross-reactivity in ELISA with Human SLAMF7 / CRACCM
Application	ELISA
Recommended Dose	ELISA: 1:5000-1:10000
Antibody Type	Monoclonal
Host Species	Rabbit
Construction	This antibody was obtained from a rabbit immunized with purified, recombinant Mouse SLAMF7 extracellular domain (rM SLAMF7; TMPY-01213; NP_653122.2; Met 1-Gly 224).
Purification	Protein A
Appearance	Liquid
Formulation	0.2 μm filtered solution in PBS
Research Background	SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruit signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. CS1 is a self ligand and homophilic interaction of CS1 regulates NK cell cytolytic activity. CRACC positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.

Related Conjugates and Formulations

Conjucates

Unconjugated

Antigen Details

Immunogen	Recombinant Protein: Mouse SLAMF7 protein (TMPY-01213)
Antigen Species	Mouse
Biology Area	Cancer Drug Targets, ITIM/ITAM Immunoreceptors and Related Molecules

Chemical Properties

Stability & Storage

Stability & Storage	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
Transport	Shipping with blue ice.

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Keywords

SLAM-7SLAM 7CS-1CS 1CD-319CD 319

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