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Bazedoxifene acetate

Name: Bazedoxifene acetate
Brand: TargetMol
SKU: T2544
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2544Cas No. 198481-33-3

Alias WAY-TES 424, WAY-140424, TSE 424

Bazedoxifene acetate (WAY-TES 424) is a novel selective estrogen receptor modulator (SERM).

Bazedoxifene acetate

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Purity: 99.97%

Catalog No. T2544Alias WAY-TES 424, WAY-140424, TSE 424Cas No. 198481-33-3

Bazedoxifene acetate (WAY-TES 424) is a novel selective estrogen receptor modulator (SERM).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	In Stock	In Stock
10 mg	$55	In Stock	In Stock
25 mg	$83	In Stock	In Stock
50 mg	$113	In Stock	In Stock
100 mg	$163	In Stock	In Stock
200 mg	$243	In Stock	In Stock
500 mg	$397	-	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.97%

Color:White to Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bazedoxifene acetate AI Summary

Bazedoxifene acetate demonstrates a diverse range of bioactivities, showing potency in inhibiting cell proliferation and cytotoxicity in various cell lines like TMD8, HCT116, and SW480. It inhibits tyrosyl-DNA phosphodiesterase 1 (TDP1) and Plasmodium falciparum proliferation, and shows potential against viruses such as Lassa Virus, Marburg Virus, and Ebola Virus. The compound also affects nuclear beta catenin stimulation in WNT3A conditioned cells, modulates insulin secretion, and influences viability and alkaline phosphatase stimulation in different cell lines. Additionally, it exhibits antiviral activity against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in Caco-2 and VERO-6 cells at a concentration of 10 μM after 48 hours, with inhibition rates of 5.64% and -0.28% respectively. Furthermore, Bazedoxifene acetate shows SARS-CoV-2 3CL-Pro protease inhibition activity with an inhibition percentage of -2.084% at 20 μM. These properties indicate its broad spectrum of bioactivities, warranting further investigation..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Bazedoxifene acetate (WAY-TES 424) is a novel selective estrogen receptor modulator (SERM).
Targets&IC50	ERβ:99 nM, ERα:26nM
Synonyms	WAY-TES 424, WAY-140424, TSE 424

Chemical Properties

Molecular Weight	530.67
Formula	C₃₂H₃₈N₂O₅
Cas No.	198481-33-3
Smiles	C(=O)(C)O.c1c(cc2c(c1)n(c(c2C)c1ccc(cc1)O)Cc1ccc(cc1)OCCN1CCCCCC1)O
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 137 mg/mL (258.16 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.54 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8844 mL	9.4221 mL	18.8441 mL	94.2205 mL
5 mM	0.3769 mL	1.8844 mL	3.7688 mL	18.8441 mL
10 mM	0.1884 mL	0.9422 mL	1.8844 mL	9.4221 mL
20 mM	0.0942 mL	0.4711 mL	0.9422 mL	4.7110 mL
50 mM	0.0377 mL	0.1884 mL	0.3769 mL	1.8844 mL
100 mM	0.0188 mL	0.0942 mL	0.1884 mL	0.9422 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc