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Divarasib

🥰Excellent
Catalog No. T9972Cas No. 2417987-45-0
Alias GDC-6036

Divarasib (GDC-6036) (GDC-6036) is an investigational, oral, high-potency and selective KRAS G12C inhibitor with an IC50 of < 0.01 μM. Divarasib irreversibly locks KRAS G12C oncoprotein in an inactive state and inhibits tumor cell growth. It is being investigated for use in solid tumors, including non-small cell lung and colorectal cancers and other types of cancer.

Divarasib

Divarasib

🥰Excellent
Purity: 99.83%
Catalog No. T9972Alias GDC-6036Cas No. 2417987-45-0
Divarasib (GDC-6036) (GDC-6036) is an investigational, oral, high-potency and selective KRAS G12C inhibitor with an IC50 of < 0.01 μM. Divarasib irreversibly locks KRAS G12C oncoprotein in an inactive state and inhibits tumor cell growth. It is being investigated for use in solid tumors, including non-small cell lung and colorectal cancers and other types of cancer.
Pack SizePriceAvailabilityQuantity
1 mg$245In Stock
5 mg$612In Stock
10 mg$869In Stock
25 mg$1,320In Stock
50 mg$1,780In Stock
100 mg$2,380In Stock
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Purity:99.83%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
Divarasib (GDC-6036) (GDC-6036) is an investigational, oral, high-potency and selective KRAS G12C inhibitor with an IC50 of < 0.01 μM. Divarasib irreversibly locks KRAS G12C oncoprotein in an inactive state and inhibits tumor cell growth. It is being investigated for use in solid tumors, including non-small cell lung and colorectal cancers and other types of cancer.
Targets&IC50
KRas (G12C):< 0.01 μM, HCC1171 cells:2 nM (EC50)
In vitro
Divarasib exhibits a potency with an EC50 value of 2 nM in K-Ras G12C-alkylation HCC1171 cells.[2]
In vivo
Administration of Divarasib (10-100 mg/kg/day; PO for 7 days) results in a reduction in the ratio of free KRAS G12C.[1]
SynonymsGDC-6036
Chemical Properties
Molecular Weight622.06
FormulaC29H32ClF4N7O2
Cas No.2417987-45-0
SmilesC[C@H]1CN(CCN1c1nc(OC[C@@H]2CCCN2C)nc2c(F)c(c(Cl)cc12)-c1nc(N)cc(C)c1C(F)(F)F)C(=O)C=C
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 90.0 mg/mL (144.7 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.6076 mL8.0378 mL16.0756 mL80.3781 mL
5 mM0.3215 mL1.6076 mL3.2151 mL16.0756 mL
10 mM0.1608 mL0.8038 mL1.6076 mL8.0378 mL
20 mM0.0804 mL0.4019 mL0.8038 mL4.0189 mL
50 mM0.0322 mL0.1608 mL0.3215 mL1.6076 mL
100 mM0.0161 mL0.0804 mL0.1608 mL0.8038 mL

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Keywords

KRAS G12CGDC6036GDC 6036Divarasib
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