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Tyroserleutide

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Catalog No. TP1472Cas No. 138168-48-6

Tyroserleutide (YSL), a small molecular tripeptide isolated from porcine spleen degradation products, inhibits the growth and metastasis of human hepatocellular carcinoma (HCC) both in vitro and in vivo.

Tyroserleutide
Other Forms of Tyroserleutide:
Tyroserleutide TFA (138168-48-6 free base)TP1558
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Tyroserleutide

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🥰Excellent
Catalog No. TP1472Cas No. 138168-48-6
Tyroserleutide (YSL), a small molecular tripeptide isolated from porcine spleen degradation products, inhibits the growth and metastasis of human hepatocellular carcinoma (HCC) both in vitro and in vivo.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$133In StockIn Stock
2 mg$197In StockIn Stock
5 mg$298In StockIn Stock
10 mg$453In StockIn Stock
25 mg$747In StockIn Stock
50 mg$1,050In StockIn Stock
100 mg$1,420In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:>99.99%
Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
Tyroserleutide (YSL), a small molecular tripeptide isolated from porcine spleen degradation products, inhibits the growth and metastasis of human hepatocellular carcinoma (HCC) both in vitro and in vivo.
In vitro
Tyroserleutide (YSL) exhibits immunomodulatory properties, notably enhancing concanavalin (ConA) induced proliferation of mouse spleen lymphocytes, augmenting phagocytosis in mouse peritoneal macrophages, and boosting natural killer (NK) cell activity[1]. Additionally, as an immunotherapeutic tripeptide, YSL promotes apoptosis in hepatocarcinoma cells (H22) by downregulating Bcl-2 and cyclin D1 expression[2], establishing it as an effective agent for liver tumor cell apoptosis induction[2]. Moreover, YSL effectively inhibits tumor growth and cell migration without causing significant toxicities in major organs[2].
Chemical Properties
Molecular Weight381.42
FormulaC18H27N3O6
Cas No.138168-48-6
SmilesC([C@@H](C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)CO)=O)N)C1=CC=C(O)C=C1
Relative Density.1.293 g/cm3 (Predicted)
SequenceH-Tyr-Ser-Leu-OH
Sequence ShortYSL
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: Soluble

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

YSLTyroserleutidetumortripeptideInhibitorinhibitAntitumor
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