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5,5-Dimethyloxazolidine-2,4-dione
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Catalog No. T1234Cas No. 695-53-4
Alias Dimethyloxazolidinedione, Dimethadione, Dimethadion
5,5-Dimethyloxazolidine-2,4-dione (Dimethadione) is an anticonvulsant that is the active metabolite of TRIMETHADIONE.
5,5-Dimethyloxazolidine-2,4-dione
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Purity: 99.12%
Catalog No. T1234Alias Dimethyloxazolidinedione, Dimethadione, DimethadionCas No. 695-53-4
5,5-Dimethyloxazolidine-2,4-dione (Dimethadione) is an anticonvulsant that is the active metabolite of TRIMETHADIONE.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 mg | $29 | In Stock | In Stock | |
| 100 mg | Preferential | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.12%
Appearance:Solid
Color:White
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Product Introduction
5,5-Dimethyloxazolidine-2,4-dione AI Summary
5,5-Dimethyloxazolidine-2,4-dione exhibits significant bioactivity in various biological assays. It acts as an inhibitor of USP1/UAF1, enhancing Schwann cell viability (S16) and blocking Ebola virus entry with potency ranging from 7.079 µM to 44.67 µM. It effectively inhibits sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar concentration of 10 µM, with an inhibition rate of 109.09%. Additionally, it inhibits human BSEP with an IC50 value greater than 1,000,000 nM and shows low binding affinity to human carbonic anhydrase 2 (Kd > 2,000,000 nM).
In antiviral studies against SARS-CoV-2, 5,5-Dimethyloxazolidine-2,4-dione exhibits varying degrees of effectiveness. It shows a low inhibition index of 0.04716 in Vero E6 cells and inhibits SARS-CoV-2 induced cytotoxicity of Caco-2 cells by 18.24% at 10 µM after 48 hours. Additionally, it inhibits SARS-CoV-2 3CL-Pro protease by 10.56% at 20 µM. However, in VERO-6 cells, its inhibition of SARS-CoV-2 induced cytotoxicity is only 0.12% at 10 µM with an IC50 value greater than 20,000 nM.
In enzymatic assays, 5,5-Dimethyloxazolidine-2,4-dione shows limited inhibitory activity against human HDAC6, with a -14.46% inhibition using a commercial peptide substrate and 5.33% inhibition with a custom peptide substrate. These findings indicate that 5,5-Dimethyloxazolidine-2,4-dione has potential bioactivity in a range of biological processes, although its effectiveness varies considerably across different targets and conditions..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 5,5-Dimethyloxazolidine-2,4-dione (Dimethadione) is an anticonvulsant that is the active metabolite of TRIMETHADIONE. |
| Synonyms | Dimethyloxazolidinedione, Dimethadione, Dimethadion |
| Molecular Weight | 129.11 |
| Formula | C5H7NO3 |
| Cas No. | 695-53-4 |
| Smiles | CC1(C)C(=O)NC(=O)O1 |
| Relative Density. | 1.243g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 78 mg/mL (604.14 mM), Sonication is recommended. DMSO: 78 mg/mL (604.14 mM), Sonication is recommended. H2O: 77 mg/mL (596.39 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (15.49 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/Ethanol/DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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