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Anti-Phospho-STAT1 (Tyr701) Polyclonal Antibody 2

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Catalog No. TMAC-03869

Anti-Phospho-STAT1 (Tyr701) Polyclonal Antibody is a Rabbit antibody targeting Phospho-STAT1 (Tyr701). Anti-Phospho-STAT1 (Tyr701) Polyclonal Antibody can be used in WB,IHC.

Anti-Phospho-STAT1 (Tyr701) Polyclonal Antibody 2

Anti-Phospho-STAT1 (Tyr701) Polyclonal Antibody 2

😃Good
Catalog No. TMAC-03869
Anti-Phospho-STAT1 (Tyr701) Polyclonal Antibody is a Rabbit antibody targeting Phospho-STAT1 (Tyr701). Anti-Phospho-STAT1 (Tyr701) Polyclonal Antibody can be used in WB,IHC.
Pack SizePriceAvailabilityQuantity
50 μL$2177-10 days
100 μL$3167-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-STAT1 (Tyr701) Polyclonal Antibody is a Rabbit antibody targeting Phospho-STAT1 (Tyr701). Anti-Phospho-STAT1 (Tyr701) Polyclonal Antibody can be used in WB,IHC.
Ig Type
IgG
Reactivity
Human,Mouse,Rat
Application
Antibody Type
Polyclonal
Host SpeciesRabbit
ConstructionPolyclonal Antibody
PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
AppearanceLiquid
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Research BackgroundSignal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-a and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
Peptide sequence around phosphorylation site of tyrosine 701 (T-G-Y(p)-I-K) derived from Human STAT1
Antigen Species
human
Uniprot ID
Chemical Properties
Molecular WeightActual: 84, 91 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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