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Anti-Phospho-STAT1 (Tyr701) Polyclonal Antibody 2 (Synonyms: STAT1 (p-Y701), STAT1 (p-Tyr701), p-STAT1 (Y701)|...)
Catalog No. TMAC-03869 Copy Product Info
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Anti-Phospho-STAT1 (Tyr701) Polyclonal Antibody is a Rabbit antibody targeting Phospho-STAT1 (Tyr701). Anti-Phospho-STAT1 (Tyr701) Polyclonal Antibody can be used in IHC,WB.
Anti-Phospho-STAT1 (Tyr701) Polyclonal Antibody 2
Copy Product Info🥰Excellent
Catalog No. TMAC-03869
Synonyms STAT1 (p-Y701), STAT1 (p-Tyr701), p-STAT1 (Y701), p-STAT1 (Tyr701)
Anti-Phospho-STAT1 (Tyr701) Polyclonal Antibody is a Rabbit antibody targeting Phospho-STAT1 (Tyr701). Anti-Phospho-STAT1 (Tyr701) Polyclonal Antibody can be used in IHC,WB.
Anti-Phospho-STAT1
(Tyr701) Polyclonal Antibody 2
(Tyr701) Polyclonal Antibody 2
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $217 | 7-10 days | 7-10 days | |
| 100 μL | $316 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-Phospho-STAT1 (Tyr701) Polyclonal Antibody is a Rabbit antibody targeting Phospho-STAT1 (Tyr701). Anti-Phospho-STAT1 (Tyr701) Polyclonal Antibody can be used in IHC,WB. |
| Synonyms | STAT1 (p-Y701), STAT1 (p-Tyr701), p-STAT1 (Y701), p-STAT1 (Tyr701) |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using STAT1 (Phospho-Tyr701) Antibody TMAC-03869 (left) or the same antibody preincubated with blocking peptide (right). 2. Western blot analysis of extracts from MEF cells untreated or treated with interferon-ɤ (IFNɤ) using STAT1 (Phospho-Tyr701) Antibody TMAC-03869. 3. Western blot analysis of extracts from Hela cells, treated with IFNa or calf intestinal phosphatase (CIP), using STAT1 (Phospho-Tyr701) Antibody TMAC-03869.    |
| Application | |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Appearance | Liquid |
| Formulation | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-a and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 701 (T-G-Y(p)-I-K) derived from Human STAT1 |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Actual: 84, 91 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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