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Nemifitide acetate(173240-15-8 free base)

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Catalog No. TP1127L1
Alias INN 00835 acetate

Nemifitide acetate(173240-15-8 free base) (INN 00835 acetate) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action. It is a peptide analog of melanocyte-inhibiting factor (MIF).

Nemifitide acetate(173240-15-8 free base)
Other Forms of Nemifitide acetate(173240-15-8 free base):
Nemifitide diTFATP1127204992-09-6
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Nemifitide acetate(173240-15-8 free base)

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Purity: 97.97%
Catalog No. TP1127L1Alias INN 00835 acetate
Nemifitide acetate(173240-15-8 free base) (INN 00835 acetate) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action. It is a peptide analog of melanocyte-inhibiting factor (MIF).
Pack SizePriceAvailabilityQuantity
1 mg$121In Stock
5 mg$233In Stock
10 mg$412In Stock
25 mg$686In Stock
50 mg$977In Stock
100 mg$1,320In Stock
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Purity:97.97%
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Product Introduction

Bioactivity
Description
Nemifitide acetate(173240-15-8 free base) (INN 00835 acetate) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action. It is a peptide analog of melanocyte-inhibiting factor (MIF).
In vitro
In-vitro studies indicate that both nemifitide and its active metabolite (M1) bind at micromolar concentrations to several receptors including the 5-HT2A, 5-HT2C, melanocortin MC4, MC5 and bombesin[3].
In vivo
Nemifitide (0.3 mg/kg; IP; daily; for 14 days) significantly increases swimming in the FSL rats after just 5 days of treatment and has long-lasting effect[2]. Nemifitide (0.0125-15.0 mg/kg) significantly increases swimming in the FSL rats at both low (0.025-0.3 mg/kg) and high (3.0-15.0 mg/kg) doses but not at intermediate (0.4-2.4 mg/kg) doses[2].
SynonymsINN 00835 acetate
Chemical Properties
Molecular Weight754.85
FormulaC35H47FN10O8
SmilesO=C(N[C@H](C(NCC(N[C@H](C(N)=O)CC1=CNC2=CC=CC=C21)=O)=O)CCC/N=C(N)\N)[C@H]3N(C([C@@H](N)CC4=CC=C(F)C=C4)=O)C[C@H](O)C3.CC(O)=O
Relative Density.no data available
SequenceH-Phe(4-F)-Hyp-Arg-Gly-Trp-NH2
Sequence ShortXXRGW
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 10 mM, Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.3248 mL6.6238 mL13.2477 mL66.2383 mL
5 mM0.2650 mL1.3248 mL2.6495 mL13.2477 mL
10 mM0.1325 mL0.6624 mL1.3248 mL6.6238 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

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