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Hemoglobin

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Catalog No. TRP-00189Cas No. 9008-02-0

Haemoglobin is an iron-containing oxygen-binding protein and a globin containing haem, present in red blood cells, capable of transporting oxygen from the lungs to tissues. Haemoglobin is a multifunctional molecule involved in numerous enzymatic catalysis, nitric oxide metabolism, pH regulation, and maintaining redox balance, amongst other functions.

Hemoglobin

Hemoglobin

😃Good
Catalog No. TRP-00189Cas No. 9008-02-0
Haemoglobin is an iron-containing oxygen-binding protein and a globin containing haem, present in red blood cells, capable of transporting oxygen from the lungs to tissues. Haemoglobin is a multifunctional molecule involved in numerous enzymatic catalysis, nitric oxide metabolism, pH regulation, and maintaining redox balance, amongst other functions.
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500 mg$31-In Stock
1 g$49-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Appearance:Solid
Color:Brown
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Product Introduction

Bioactivity
Description
Haemoglobin is an iron-containing oxygen-binding protein and a globin containing haem, present in red blood cells, capable of transporting oxygen from the lungs to tissues. Haemoglobin is a multifunctional molecule involved in numerous enzymatic catalysis, nitric oxide metabolism, pH regulation, and maintaining redox balance, amongst other functions.
In vitro
Hemoglobin (1-50 μM) treatment of HepG2 cells for 6 hours significantly increased α1-microglobulin levels and elevated reactive oxygen species content. [3]
In vivo
In the lipopolysaccharide (LPS)-induced rat endotoxemia model, Hemoglobin (300 mg/kg) was intravenously administered 16 hours before LPS injection. At 24 hours post-LPS injection, Hemoglobin significantly alleviated neutrophil alveolitis, increased the expression and activity of heme oxygenase-1 (HO-1) in rat lung tissues, and improved the survival rate of the rats.
Chemical Properties
Cas No.9008-02-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: 15 mg/mL, Sonication is recommended.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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