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PH-002

Name: PH-002
Brand: TargetMol
SKU: T16518
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16518Cas No. 1311174-68-1

PH-002, an inhibitor targeting the intramolecular domain interaction of apolipoprotein (apo) E4 in neuronal cells, additionally enhances mitochondrial motility and promotes neurite outgrowth, thereby countering related impairments.

PH-002

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Purity: 99.08%

Catalog No. T16518Cas No. 1311174-68-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$42	In Stock	In Stock
5 mg	$97	In Stock	In Stock
10 mg	$163	In Stock	In Stock
25 mg	$363	In Stock	In Stock
50 mg	$589	In Stock	In Stock
100 mg	$843	-	In Stock
200 mg	$1,160	-	In Stock
1 mL x 10 mM (in DMSO)	$108	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.08%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	PH-002, an inhibitor targeting the intramolecular domain interaction of apolipoprotein (apo) E4 in neuronal cells, additionally enhances mitochondrial motility and promotes neurite outgrowth, thereby countering related impairments.
Targets&IC50	ApoE4 (FRET):116 nM
In vitro	PH-002 inhibits intramolecular domain interaction of apolipoprotein (apo) E4 in neuronal cells (IC50: 116 nM in FRET) [1].
In vivo	PH-002 (100 nM) promotes dendritic spine development in primary neurons from NSE-apoE4 transgenic mice to levels similar to those in NSE-apoE3 neurons (apoE3-expressing primary neurons treated with PH-002 show results comparable to untreated neurons). Additionally, PH-002 enhances COX1 levels in primary neurons from the NSE-apoE4 transgenic mouse cortex and hippocampus, increasing COX1 by ~60% after 4 days of treatment at 200 nM [2].

Chemical Properties

Molecular Weight	491.58
Formula	C₂₇H₃₃N₅O₄
Cas No.	1311174-68-1
Smiles	Cn1nc(CC(=O)Nc2ccc(CN3CCN(CC3)C(=O)OC(C)(C)C)cc2)c2ccccc2c1=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 75 mg/mL (152.57 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0343 mL	10.1713 mL	20.3426 mL	101.7128 mL
5 mM	0.4069 mL	2.0343 mL	4.0685 mL	20.3426 mL
10 mM	0.2034 mL	1.0171 mL	2.0343 mL	10.1713 mL
20 mM	0.1017 mL	0.5086 mL	1.0171 mL	5.0856 mL
50 mM	0.0407 mL	0.2034 mL	0.4069 mL	2.0343 mL
100 mM	0.0203 mL	0.1017 mL	0.2034 mL	1.0171 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc