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Anti-UCMA Polyclonal Antibody
Catalog No. TMAB-13969 Copy Product Info
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Anti-UCMA Polyclonal Antibody is a Rabbit antibody targeting UCMA. Anti-UCMA Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-UCMA Polyclonal Antibody
Copy Product Info🥰Excellent
Catalog No. TMAB-13969
Anti-UCMA Polyclonal Antibody is a Rabbit antibody targeting UCMA. Anti-UCMA Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-UCMA Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-UCMA Polyclonal Antibody is a Rabbit antibody targeting UCMA. Anti-UCMA Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Rat (predicted:Human,Mouse) |
| Verified Activity | Paraformaldehyde-fixed, paraffin embedded (young rat paw); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (UCMA) Polyclonal Antibody, Unconjugated (TMAB-13969) at 1: 200 overnight at 4°C, followed by conjugation to the secondary antibody and DAB staining. |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Secreted > extracellular space > extracellular matrix. |
| Tissue Specificity | Predominantly expressed in resting chondrocytes. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | UCMA is a 138 amino acid secreted protein that is highly expressed in resting chrondrocytes in developing long bones and is thought to function in the early phase of chrondrocyte differentiation. A furin-like protease processes UCMA into an N-terminal 37 amino acid peptide and a C-terminal 74 amino acid peptide, which is referred to as Unique cartilage matrix-associated protein C-terminal fragment (Ucma-C). Introduction of recombinant Ucma-C interferes with osteogenic differentiation of mesenchymal stem cells, MC3T3-E1 preosteoblasts and primary osteoblasts. This suggests that Ucma may be involved in the negative regulation of osteogenic differentiation of osteochondrogenic precursor cells at the cartilage-bone interface and in peripheral zones of fetal cartilage. |
| Immunogen | KLH conjugated synthetic peptide: human UCMA |
| Antigen Species | Human |
| Gene Name | UCMA |
| Gene ID | |
| Protein Name | Unique cartilage matrix-associated protein |
| Uniprot ID | |
| Function | May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface. |
| Molecular Weight | Theoretical: 14 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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