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Anti-RUNX1/RUNX2/RUNX3 Antibody (1I929)
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Catalog No. TMAB-12426
Anti-RUNX1/RUNX2/RUNX3 Antibody (1I929) is a Rabbit antibody targeting RUNX1/RUNX2/RUNX3. Anti-RUNX1/RUNX2/RUNX3 Antibody (1I929) can be used in WB,IHC-P,IHC-Fr,IF,FCM,ICC/IF.
Anti-RUNX1/RUNX2/RUNX3 Antibody (1I929)
Anti-RUNX1/RUNX2/RUNX3 Antibody (1I929)
😃Good
Catalog No. TMAB-12426
Anti-RUNX1/RUNX2/RUNX3 Antibody (1I929) is a Rabbit antibody targeting RUNX1/RUNX2/RUNX3. Anti-RUNX1/RUNX2/RUNX3 Antibody (1I929) can be used in WB,IHC-P,IHC-Fr,IF,FCM,ICC/IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $150 | 7-10 days | 7-10 days | |
| 50 μL | $262 | 7-10 days | 7-10 days | |
| 100 μL | $472 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-RUNX1/RUNX2/RUNX3 Antibody (1I929) is a Rabbit antibody targeting RUNX1/RUNX2/RUNX3. Anti-RUNX1/RUNX2/RUNX3 Antibody (1I929) can be used in WB,IHC-P,IHC-Fr,IF,FCM,ICC/IF. |
| Clone | 1I929 |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:50-200; IHC-Fr: 1:50-200; IF: 1:50-200; FCM: 1:50-100; ICC/IF: 1:100-500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. |
| Tissue Specificity | Specifically expressed in osteoblasts. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Concentration | 1mg/ml |
| Research Background | This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2008]. |
| Immunogen | A synthesized peptide: human RUNX |
| Antigen Species | Human |
| Gene Name | RUNX2 |
| Gene ID | |
| Protein Name | Runt-related transcription factor 2 |
| Uniprot ID | |
| Function | Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters (By similarity). Inhibits MYST4-dependent transcriptional activation. [SUBUNIT] Interaction with SATB2 results in enhanced DNA binding and transactivation by these transcription factors (By similarity). Heterodimer of an alpha and a beta subunit. Interacts with HIVEP3 (By similarity). The alpha subunit binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with XRCC6 (Ku70) and XRCC5 (Ku80). Interacts with MYST3 and MYST4. |
| Molecular Weight | Theoretical: 51 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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