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Prednisolone hemisuccinate

Name: Prednisolone hemisuccinate
Brand: TargetMol
SKU: T13825
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13825Cas No. 2920-86-7

Alias Prednisolone 21-hemisuccinate

Prednisolone hemisuccinate is a soluble glucocorticoid and cortisol, a prodrug of the glucocorticoid (GR) agonist Prednisone, which exerts anti-inflammatory, immunosuppressive, and antiallergic effects by binding to GR receptor, and is commonly used in systemic lupus erythematosus, acute dermatologic conditions, and arthritis.

Prednisolone hemisuccinate

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Purity: 99.96%

Catalog No. T13825Alias Prednisolone 21-hemisuccinateCas No. 2920-86-7

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$40	-	In Stock
50 mg	$58	-	In Stock
100 mg	$82	-	In Stock
200 mg	$127	-	In Stock
1 mL x 10 mM (in DMSO)	$39	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.96%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Prednisolone hemisuccinate is a soluble glucocorticoid and cortisol, a prodrug of the glucocorticoid (GR) agonist Prednisone, which exerts anti-inflammatory, immunosuppressive, and antiallergic effects by binding to GR receptor, and is commonly used in systemic lupus erythematosus, acute dermatologic conditions, and arthritis.
In vitro	Methods: Peripheral blood mononuclear cells containing NK cells were isolated and cocultured with target K562 cells at three different effector-to-target (E:T) ratios of 50:1, 25:1, and 12.5:1. Prednisolone hemisuccinate or IVIG were then added to the tubes at an E:T ratio of 50:1 to assess the inhibitory effect. Percent killing was recorded and statistically analyzed using the Student t test. Results: In experiments with an E:T ratio of 50:1 and either Prednisolone hemisuccinate or IVIG in the coculture, the mean target cell killing rate was 26.4%. In cultures using the same E:T ratio, this killing rate was significantly reduced in the presence of IVIG (9.9%) or Prednisolone hemisuccinate (13.6%) (P < 0.001 for both analyses). Prednisolone hemisuccinate was able to inhibit the cytolytic activity of NK cells. [1]
Synonyms	Prednisolone 21-hemisuccinate

Chemical Properties

Molecular Weight	460.52
Formula	C₂₅H₃₂O₈
Cas No.	2920-86-7
Smiles	C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@]2(O)C(=O)COC(=O)CCC(O)=O
Relative Density.	1.1796 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (325.72 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.69 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1715 mL	10.8573 mL	21.7146 mL	108.5729 mL
5 mM	0.4343 mL	2.1715 mL	4.3429 mL	21.7146 mL
10 mM	0.2171 mL	1.0857 mL	2.1715 mL	10.8573 mL
20 mM	0.1086 mL	0.5429 mL	1.0857 mL	5.4286 mL
50 mM	0.0434 mL	0.2171 mL	0.4343 mL	2.1715 mL
100 mM	0.0217 mL	0.1086 mL	0.2171 mL	1.0857 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc